Linking the IL-17A immune response with NMR-based faecal metabolic profile in IBD patients treated with Mastiha - 16/04/21
páginas | 8 |
Iconografías | 4 |
Vídeos | 0 |
Otros | 0 |
Abstract |
Dysregulation of intestinal immune response plays a critical role in the pathogenesis of Inflammatory Bowel Disease (IBD). Mastiha’s anti-inflammatory properties are well established. Our aim was to investigate Mastiha’s regulatory effect on IL-17A serum levels in IBD patients. Alterations of the faecal metabolome as a functional readout of microbial activity were explored. A randomized, double-blind, placebo-controlled, parallel-group design was applied for a total of 3 months in active and 6 months in inactive IBD patients. Serum IL-17A increased significantly in Mastiha group (p = 0.006), and the mean change differed significantly between Mastiha and placebo (p = 0.003) even after adjusting for age, sex and BMI (p = 0.001) in inactive patients. In inactive UC patients IL-17A decreased significantly only in placebo (p = 0.033). No significant differences were detected in active disease. Faecal metabolomics indicated that intervention with Mastiha influenced considerably the metabolic profile of IBD patients in remission exhibiting, in between others, increased levels of glycine and tryptophan. Glycine has been proposed to have a therapeutic effect against IBD, while tryptophan derivatives are involved in immunoregalutory mechanisms, such as the Th17 cells differentiation. Thus, it is quite possible that the immunoregulatory role of Mastiha in quiescent IBD involves the regulation of Th17 cells function and differentiation.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | Mastiha increases IL-17A serum levels in IBD patients in remission. |
• | Mastiha alters the stool metabolic profile of IBD patients in remission. |
• | Mastiha increases levels of Gly, Ala, Try, Phe and Tyr in stools of IBD patients. |
Abbreviations : AhR, BCAAs, CD, CRP, HBI, HMDB, IBD, IBDQ, IL, ITT, NMR, OPLS DA, PCA, PMS, SCFAs, Th, TSP, UC
Keywords : Mastiha, Inflammatory bowel diseases, Faecal metabolomics, Interleukin-17A
Esquema
Vol 138
Artículo 111535- juin 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?