Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease - 04/05/21
Doi : 10.1016/j.neurad.2019.03.015
Roxana Ameli a, ⁎ 
, Charles R.G. Guttmann b, Juan Carlos Prieto b, Fabien Rollot c, Miklos Palotai b, Sandra Vukusic d, Romain Marignier d, e, François Cotton f
, Charles R.G. Guttmann b, Juan Carlos Prieto b, Fabien Rollot c, Miklos Palotai b, Sandra Vukusic d, Romain Marignier d, e, François Cotton fGroup Members for OFSEP Imaging Working Group
René Anxionnat g , Jean-Paul Armspach h , Bertrand Audoin i , Christian Barillot j , Isabelle Berry k , Fabrice Bonneville l , Claire Boutet m , Giovanni Castelnovo n , Frédéric Cervenanski o , Mikael Cohen p , Olivier Commowick q , Jerome De Seze r , Vincent Dousset s, t, u , Francoise Durand-Dubief v , Gilles Edan w , Jean-Christophe Ferre w , Damien Galanaud x , Tristan Glattard y , Sylvie Grand z, aa , Justine Guillaumont q , Rémy Guillevin ab , Salem Hannoun ac , Fabrice Heitz ad , Alexandre Krainik ae , Stéphane Kremer af , Pierre Labauge ag , Nicolas Menjot De Champfleur ah , Jean-Philippe Ranjeva ai , Jean-Amédée Roch aj , Dominique Sappey-Marinier ak , Julien Savatovsky al , Bruno Stankoff am , Ayman Tourbah an , Thomas Tourdias ao, t, u , Bruno Brochet ap
, Jean-Paul Armspach h , Bertrand Audoin i , Christian Barillot j , Isabelle Berry k , Fabrice Bonneville l , Claire Boutet m , Giovanni Castelnovo n , Frédéric Cervenanski o , Mikael Cohen p , Olivier Commowick q , Jerome De Seze r , Vincent Dousset s, t, u , Francoise Durand-Dubief v , Gilles Edan w , Jean-Christophe Ferre w , Damien Galanaud x , Tristan Glattard y , Sylvie Grand z, aa , Justine Guillaumont q , Rémy Guillevin ab , Salem Hannoun ac , Fabrice Heitz ad , Alexandre Krainik ae , Stéphane Kremer af , Pierre Labauge ag , Nicolas Menjot De Champfleur ah , Jean-Philippe Ranjeva ai , Jean-Amédée Roch aj , Dominique Sappey-Marinier ak , Julien Savatovsky al , Bruno Stankoff am , Ayman Tourbah an , Thomas Tourdias ao, t, u , Bruno Brochet ap g INSERM U947 Imagerie Adaptative Diagnostique et Interventionnelle, Service de neuroradiologie, CHU de Nancy, 29 avenue du Maréchal de Lattre de Tassigny, 54035 Nancy, France
h Université de Strasbourg, IPB-ICube, CNRS UMR 7357, FMTS, 4, rue Kirschleger, 67085 Strasbourg Cedex, France
i APHM, Hôpital de la Timone, 264 Rue Saint-Pierre, 13005 Marseille, France
j Université Rennes I, Université Européenne de Bretagne, INSERM, CNRS, INRIA Rennes - Bretagne Atlantique, Campus de Beaulieu, 263 Avenue Général Leclerc, 35042 Rennes, France
k Université Toulouse III, INSERM, Service de médecine nucléaire CHU de Toulouse - Hôtel Dieu, 2 rue Viguerie, TSA 80035, 31059 Toulouse, France
l Université Toulouse III, Service de Neuroradiologie, Hôpital Pierre Paul Riquet, et Inserm, U 825, CHU Purpan, 1, Place du Dr Baylac, 31000 Toulouse, France
m Service de Radiologie, CHU Saint Etienne–Hôpital Nord, 42055 Saint Etienne Cedex 2, France
o CREATIS, CNRS UMR 5220& INSERM - Bât L. de Vinci (’401’), 21 avenue Jean Cappelle, 69621 Villeurbanne cedex, France
p Service de neurologie, Hôpital Pasteur, 30 avenue de la voie romaine, 06000 Nice, France
q Inria Rennes- Bretagne Atlantique (Unité/Projet VisAGeS U746), Campus de Beaulieu, 263 Avenue Général Leclerc, 35042 Rennes, France
r Université de Strasbourg, CNRS, CHU de Strasbourg, 1 place de l’hôpital, 67091 Strasbourg Cedex, France
s University of Bordeaux, Institut de Bio-Imagerie de Bordeaux UMS 3428, 33000 Bordeaux, France
t INSERM, U862, Physiopathologie de la plasticité neuronale, 33000 Bordeaux, France
u CHU de Bordeaux, Service de NeuroImagerie Diagnostique de Thérapeutique, 33000 Bordeaux, France
v CREATIS, CNRS UMR 5220& INSERM U1044, Hôpital Neurologique - service de neurologie A, 59 boulevard Pinel, 69677 Bron Cedex, France
w Service de neurologie CHU de Rennes, 2 rue Henri le Guilloux, 35033 Rennes Cedex 9, France
x APHP, Université Pierre et Marie Curie, INSERM, CNRS, Service de neuroradiologie GH, Pitié Salpêtrière, 47 boulevard de l’hôpital, 75651 Paris cedex 13, France
y CREATIS, CNRS UMR 5220& INSERM U1044- Bât L. de Vinci (’401’), 21 avenue Jean Cappelle, 69621 Villeurbanne cedex, France
z University Grenoble Alpes, Grenoble Institute of Neurosciences, Grenoble, France
aa Grenoble University Hospital, Department of Neuroradiology and MRI, Grenoble, Inserm, U836, 38042, Grenoble, France
ab Service de neuroradiologie CHU de Poitiers, 2 Rue de la Milétrie, 86021 Poitiers, France
ac OFSEP/CREATIS, CNRS UMR 5220& INSERM U1044, CERMEP-Imagerie du Vivant, 59 Boulevard Pinel, 69677 Bron Cedex, France
ad ICube, UMR CNRS 7357, Université de Strasbourg, Télécom Physique Strasbourg, 300 Bd Sébastien Brant, CS 10413, 67412 Illkirch Cedex, France
ae University Grenoble Alpes, Grenoble Institute of Neurosciences, Grenoble University Hospital, Department of Neuroradiology and MRI, Inserm, U836, 38042 Grenoble, France
af Université de Strasbourg, ICube CNRS UMR 7357, FMTS, CHU de Strasbourg, 1 place de l’hôpital, 67091 Strasbourg Cedex, France
ag Université Montpellier-Nîmes I, INSERM, CNRS, Service de neurologie, CHU de Montpellier - Centre A. Benech, avenue Doyen Giraud, 34295 Montpellier cedex 5, France
ah Institut d’Imagerie Fonctionnelle Humaine (I2FH) Hôpital Gui de Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France
ai APHM, Université Aix-Marseille II, CRMBM UMR CNRS 7339, Faculté de Médecine, 27 Bvd Jean Moulin, 13385 Marseille cedex 05, France
aj CHU de Lyon, Hôpital Jean Mermoz, 55 Avenue Jean Mermoz, 69008 Lyon 08, France
ak Université Claude Bernard Lyon 1, CREATIS, CNRS UMR 5220& INSERM U1044, CERMEP-Imagerie du Vivant, 59 Boulevard Pinel, 69677 Bron Cedex, France
al Fondation Rothschild, 25 rue Manin, 75019 Paris, France
am APHP, Université Pierre et Marie Curie, INSERM, HUEP Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France
an URCA, INSERM, CNRS, CHU de Reims, 45 rue Cognacq-Jay, 51092 Reims Cedex, France
ao University Bordeaux, 33000 Bordeaux, France
ap Department of Neurology, CHU Bordeaux, Bordeaux, France
COPIL of OFSEP
Michel Clanet aq , Nathalie Dufay ar , David Laplaud as, at, au , Marie-Claire Maze ar , Thibault Moreau av , Cédric Trolliet aw , Bernard Frangoulis ax, ay, az , Javier Olaiz ax , Jean Pelletier ba
, Nathalie Dufay ar , David Laplaud as, at, au , Marie-Claire Maze ar , Thibault Moreau av , Cédric Trolliet aw , Bernard Frangoulis ax, ay, az , Javier Olaiz ax , Jean Pelletier ba aq Department of Neurology, CHU Toulouse, Toulouse, France
ar Hospices Civils de Lyon, Hôpital Neurologique, Service de Neurologie A, 69677 Bron, France
as INSERM, UMR 1064, 44093 Nantes, France
at Neurology Department, Nantes Hospital Nantes, 44093 Nantes, France
au INSERM 004, Centre d’Investigation Clinique Nantes, 44093 Nantes, France
av Service de Neurologie, CHU de Dijon, Dijon, France
aw Observatoire Français de la Sclérose en Plaques (OFSEP), 69677 Lyon, France
ax Service de Neurologie A and Fondation Eugène Devic EDMUS contre la Sclérose en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France
ay Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Equipe Neuro-oncologie et Neuro-inflammation, Université de Lyon, Lyon, France
az Université Lyon 1, Lyon, France
ba APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Department of Neurology, Marseille, France
NOMADMUS study group
Bertrand Audoin bb, Bertrand Bourre bc, David Brassat bd, Philippe Cabre be, Jean-Philippe Camdessanche bf, William Camu bg, Olivier Casez bh, Giovanni Castelnovo bi, Pierre Clavelou bj, Nicolas Collongues bk, Alain Creange bl, Gilles Defer bm, Marc Debouverie bn, Gilles Edan bo, Olivier Gout bp, Pierre Labauge bq, Christine Lebrun-Frenay br, Catherine Lubetzki bs, Caroline Papeix bs, Bruno Stankoff bt, Ayman Tourbah bu, Patrick Vermersch bv, Hélène Zephir bv
bb Department of Neurology, La Timone University Hospital, Marseille, France
bc Departement of Neurology, Charles Nicolle University Hospital, Rouen, France
bd Department of Neurology, Toulouse-Purpan University Hospital, Toulouse, France
be University Hospital, Fort de France, Martinique
bf University Hospital, Saint Etienne, France
bg UNCD Molecular Inut, INSERM V336, Institute of Biology, Montpellier, France
bh Departement of Neurology, Grenoble University Hospital, Grenoble, France
bi Departement of Neurology, Nîmes University Hospital, Nîmes, France
bj Department of Neurology, Montpied University Hospital, Clermont-Ferrand, France
bk UF 6961 Inflammatory diseases of the CNS, Hautepierre Hospital, Strasbourg, France
bl Neurosciences Department, Mondor University Hospital, Creteil, France
bm Department of Neurology, Caen University Hospital, Caen, France
bn Department of Neurology, Nancy University Hospital, Nancy, France
bo Department of Neurology, Rennes University Hospital, Rennes, France
bp Rothschild Foundation, Paris, France
bq Department of Neurology, Gui de Chauliac Hospital, Montpellier University Hospital, Montpellier, France
br Department of Neurology, Nice University Hospital, Nice, France
bs Neurology Unit 4, Pitié-Salpétrière University Hospital, Paris, France
bt Department of Neurology, Tenon Hospital, Paris, France
bu Department of Neurology, Reims University Hospital, Reims, France
bv Department of Neurology, EA 2686, Lille University Hospital, Lille, France
a Hôpital Neurologique et Neurochirurgical, Service de Radiologie, Bron, France
b Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
c Observatoire Français de la Sclérose en Plaques (OFSEP), Lyon, France
d Université Lyon 1, Hospices Civils de Lyon, Hôpital Neurologique, Service de Neurologie A, Bron, France
e Neuroscience Research center INSERM UMR-S1028, CNRS/UMR/5292, Lyon, France
f Université Lyon 1, Laboratoire d’Anatomie de Rockefeller; Centre Hospitalier Lyon Sud, Service de Radiologie, Pierre Bénite; CREATIS-LRMN, CNRS/UMR/5220–INSERM U630, Villeurbanne, France
⁎Corresponding author. Department of Radiology, Hôpital Pierre Wertheime, 59, bvd Pinel, 69677 Bron, France.Department of Radiology, Hôpital Pierre Wertheime59, bvd PinelBron69677France
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Graphical abstract |
Abstract |
Background and purpose |
To determine the precise incidence of lesions at sites of high Aquaporin-4 expression (hAQP4) and their possible association with known neuromyelitis optica spectrum disease (NMOSD) lesions patterns.
Materials and methods |
A retrospective analysis of brain and, when available, spinal cord MRI scans of 54 NMOSD patients recruited among the French NMOSD cohort was performed. Brain lesions were annotated as MS-like, non-specific, or evocative of NMOSD. The topography of hAQP4 was reassessed by human brain atlas. The incidence of lesions in hAQP4 and their association with lesions evocative of NMOSD was estimated.
Results |
Among those included (41/54 female, mean age: 45 years) 47/54 (87%) presented brain lesions. Twenty-six/47 (55%) had lesions in hAQP4. Thirty-two/54 patients (60%) had lesions considered evocative of NMOSD. The majority of them also presented lesions in hAQP4 (65%, 21/32). Patients with lesions in hAQP4 and lesions evocative of NMOSD demonstrated more extensive myelitis compared to the other patients (7 [6–10] versus 4 [3–5] vertebral segments, P=0.009).
Conclusion |
The coexistence of lesions evocative of NMOSD and in hAQP4 is associated with significantly more extensive myelitis, and might have pathophysiological and clinical significance.
El texto completo de este artículo está disponible en PDF.Keywords : MRI, All Demyelinating Diseases, Devic's syndrome, Aquaporin 4
Esquema
© 2019
Publicado por Elsevier Masson SAS.
Vol 48 - N° 3
P. 170-175 - mai 2021 Regresar al número
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