Distribution of Malassezia species on the skin of patients with psoriasis - 29/05/21
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| páginas | 6 |
| Iconografías | 4 |
| Vídeos | 0 |
| Otros | 0 |
Highlights |
• | M. restricta and M. globose are the predominantly present on psoriatic skin. |
• | M. furfur was only found in patients with PS. |
• | M. restricta decreased and M. globosa increased as the PASI score increased. |
• | The Malassezia species diversity was higher on psoriatic skin than on healthy skin. |
• | The Malassezia species diversity decreased as the PASI score increased. |
Abstract |
Introduction |
Malassezia species can induce the expression of interleukin-17 (IL-17), which plays an important role in the inflammatory and immune response in psoriasis (PS). The purpose of this study was to investigate the Malassezia species composition in patients with PS and healthy individuals and explore the role of Malassezia species in the pathogenesis of PS.
Materials and methods |
A total of 28 patients with PS and 10 age- and sex-matched healthy individuals participated in this study. Specimens collected from the lesional and non-lesional skin of patients with PS and the skin of healthy individuals were analyzed by using nested PCR.
Results |
The relative abundance of Malassezia species was 84.96% in healthy subjects, more than twice that in patients with PS (P<0.01). M. restricta (43.09%) and M. globosa (41.38%) were the main Malassezia species in patients with PS followed by M. furfur (4.84%) and M. sympodialis (2.49%). M. sympodialis accounted for 18. 81% of the Malassezia species in healthy subjects, which was nearly eight times higher than in patients with PS (P<0.01). Further, M. furfur was detected both on lesional and non-lesional psoriatic skin, but it was not found on the skin of healthy individuals.
Conclusions |
The Malassezia species composition in patients with PS differed from that of healthy individuals. M. restricta and M. globosa were the main Malassezia species in patients with PS.
El texto completo de este artículo está disponible en PDF.Keywords : Malassezia, Nested polymerase chain reaction, Psoriasis
Esquema
Vol 31 - N° 2
Artículo 101111- juin 2021 Regresar al número
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