Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review - 22/07/21
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SUMMARY |
Chronic myeloid leukemia (CML) is a myeloproliferative disease that results from the BCR-ABL gene-induced transformation of a primitive hematopoietic cell. This disease has been extensively studied, and, as a result, a very effective therapy has been developed: the tyrosine kinase inhibitors. Although, there is a significant knowledge about the intrinsic biology of CML cells, alterations in their bone marrow microenvironment are not yet completely understood. In this concise review, we summarized recent findings on the composition and function of the bone marrow microenvironment in CML, and their importance in the progression of the disease and treatment resistance.
El texto completo de este artículo está disponible en PDF.Keywords : Microenvironment, Leukemia, Chronic Myeloid Leukemia, Hematopoietic Stem Cells
Esquema
Vol 69 - N° 3
Artículo 103295- juillet 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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