Assessment of SARS-CoV-2 testing in children during a low prevalence period (VIGIL study 1) - 24/07/21

Doi : 10.1016/j.idnow.2021.07.004

Eleonore Eskander ^a, Camille Jung ^b, Corinne Levy ^a,^b,^c,^d,^e,⁎ , Stéphane Béchet ^a, Nathalie Blot ^f, Stéphanie Gorde ^d, Camille le Stradic ^g, Matthieu Come ^h, Robert Touitou ^a,ⁱ, Robert Cohen ^a,^b,^c,^d,^e
^a ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, 31, rue Le Corbusier, 94000 Créteil, France
^b Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France
^c Université Paris Est, IMRB-GRC GEMINI, Créteil, France
^d AFPA, Association française de Pédiatrie Ambulatoire, Saint-Germain-en-Laye, France
^e GPIP, Groupe de Pathologie Infectieuse Pédiatrique, Créteil, France
^f Centre Hospitalier Rives de Seine, Neuilly sur Seine, France
^g Centre Hospitalier de Bretagne Sud, Lorient, France
^h Centre Hospitalier Charles Nicolle, Rouen, France
ⁱ Enseignement Formation Généralistes Hospitaliers, Groupe Hospitalier Diaconesses Croix Saint Simon (GHDCSS), France

^⁎Corresponding author at: ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, 31, rue Le Corbusier, 94000 Créteil, France.ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne31, rue Le CorbusierCréteil94000France

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En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Saturday 24 July 2021
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Highlights

•	From June 1 to July 31, 2020, a pediatric cross-sectional prospective, multicenter study throughout France showed a positivity rate of 1.4% (95%CI [0.9; 2.1]) for 1,553 nasopharyngeal SARS-CoV-2 RT-PCR tests.
•	The predictive factors of positivity were age below 2 years and history of contact.
•	In an epidemic stage with low SARS-CoV-2 circulation, sampling of children with nonspecific symptoms and without known contact is probably not relevant.

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Abstract

Objectives

SARS-CoV-2 induces a broad spectrum of clinical manifestations, which overlap with other viral infections very common in children. We aimed to describe the percentage of positive SARS-CoV-2 RT-PCR tests in symptomatic and asymptomatic ambulatory children and to determine the predictive factors for positivity.

Patients and Methods

From June 1 to July 31, 2020, we conducted a cross-sectional prospective, multicenter study (13 hospital emergency units and 59 ambulatory pediatricians) throughout France. Children under 15 years of age with a prescription of nasopharyngeal SARS-CoV-2 RT-PCR test were enrolled.

Results

Among the 1,553 RT-PCR tests, 22 were positive (1.4%; 95%CI [0.9; 2.1]). In both univariate and multivariate analyses, the predictive factors for positivity were age below 2 years (OR: 4.5 [1.6; 12.7]) and history of contact (OR: 12.3 [4.6; 32.8]).