Biopsy of the oral mucosa: Does size matter? - 19/02/22

Doi : 10.1016/j.jormas.2022.02.005

Benjamin Lazzarotto ^{^{1
Lazzarotto B. & Garcia C. should be accredited with co-first authorship.},}^⁎ , Chloé Garcia ^{^{1
Lazzarotto B. & Garcia C. should be accredited with co-first authorship.}}, Carla Martinelli-Klay, Tommaso Lombardi
Unit of Oral Medicine and Pathology, Division of Oral Maxillofacial Surgery, Department of Surgery, University Hospitals of Geneva, Switzerland.

^⁎Corresponding author at: Unit of Oral Medicine and Pathology, Division of Oral Maxillofacial Surgery, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland.Unit of Oral Medicine and Pathology, Division of Oral Maxillofacial Surgery, Department of SurgeryUniversity Hospitals of GenevaGenevaSwitzerland

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Saturday 19 February 2022
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Abstract

Aim

To analyze the relation between biopsy specimen's size and the definitive diagnosis. In addition, other variables including oral mucosa region, type of disease and general versus specialist practitioner were also assessed.

Methods

Data from specimens submitted to histopathological examination between 2007 and 2017 were retrospectively analysed.

Results

We analysed data on 792 patients. Out of 1089 archived reports, 81 (7.4%) had no definitive diagnosis. Multivariate analysis rendered biopsy length as the factor influencing the possibility to reach a definitive diagnosis.

Conclusion

The size of the specimen is an important parameter to achieve a correct histopathological diagnosis of the oral lesions investigated. According to our results, it seems that a 10 mm length is adequate to optimize the biopsy outcome. No statistically differences were observed between GPDs and oral surgery specialists, probably because biopsies were performed by experienced general practitioners, although not formally trained.

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Keywords : Diagnosis, Biopsy, Oral mucosa, Oral diseases