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Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review - 22/05/22

Doi : 10.1016/j.jormas.2022.05.005 
Lucas Alves da Mota Santana a, , Walbert de Andrade Vieira b, Rani Iani Costa Gonçalo c, Marcos Antônio Lima dos Santos d, Wilton Mitsunari Takeshita a, Lucyene Miguita e,
a Department of Dentistry, Health and Biological Sciences Institute, Universidade Federal de Sergipe (UFS), Rua Cláudio Batista, s/n, Santo Antônio, Aracaju, Sergipe, 49060-102, Brazil 
b School of Dentistry of Piracicaba, Department of Restorative Dentistry, Endodontics Division, University of Campinas (UNICAMP), Av. Limeira, 901, Areião, Piracicaba, SP, 13414-903, Brazil 
c Department of Dentistry, Federal University of Rio Grande do Norte (UFRN), Av. Sen. Salgado Filho, 1787, Lagoa Nova, Natal, RN, 59056-000, Brazil 
d Department of Stomatology, Faculty of Dentistry, University of Sao Paulo (USP), Universidade de São Paulo (FOUSP), Av. Prof. Lineu Prestes, 2227 - Butantã, São Paulo, SP, 05508-000, Brazil 
e Department of Pathology, Institute of Biological Science, Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Room G3-060 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil 

Co-Corresponding author at: Lucas Alves da Mota Santana, Department of Dentistry, Universidade Federal de Sergipe (UFS), Health and Biological Sciences Institute. Rua Cláudio Batista, s/n, Santo Antônio, 49060102 Aracaju, SE, Brazil.Av. Pres. Antônio Carlos, 6627, Room G3-060 - PampulhaBelo HorizonteMG31270-901Brazil⁎⁎Corresponding author at: Lucyene Miguita, Department of Pathology, Institute of Biological Science, Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Room G3-060 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil.Rua Cláudio Batista, s/n, Santo AntônioAracajuSergipe49060-102Brazil

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ABSTRACT

This systematic review purposed to investigate reports of oral lesions in confirmed COVID-19 patients summarizing clinical characteristics, histological findings, treatment and correlation of oral lesions and COVID-19 severity. Electronic search was conducted on November 2021 using seven databases to identify case reports/series describing lesions in oral mucosa in COVID-19 confirmed cases. A total of 5,179 studies were found, being 39 eligible from 19 countries, totalling 116 cases. It was observed only COVID-19 non-vaccinated cases and no sex or age predilection. The oral lesions presentation was mostly single location (69.8%), commonly in the tongue, lips, and palate, being ulcer the main clinical presentation. According to severity index for COVID-19, the reports were more frequent in patients with mild and moderate symptoms, being 75.8% in acute phase. The oral lesion appearance in post-acute COVID-19 were described after 14 to two months after patient recovery. Histologically, keratinocytes with perinuclear vacuolization, thrombosis and mononuclear inflammatory infiltrate were also described with the presence of the virus in keratinocytes, endothelial cells, and minor salivary glands. In conclusion, health care professionals should consider COVID-19 association when patient present ulcerated oral lesions and mild to moderate symptoms for COVID-19 or had acute-COVID-19.

El texto completo de este artículo está disponible en PDF.

Keywords : COVID-19, Coronavirus, Oral lesion, Oral cavity


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© 2022  Publicado por Elsevier Masson SAS.
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