Cellular senescence in chronic lung diseases from newborns to the elderly: An update literature review - 22/03/24
Abstract |
The role of cellular senescence in age-related diseases has been fully recognized. In various age-related-chronic lung diseases, the function of alveolar epithelial cells (AECs) is impaired and alveolar regeneration disorders, especially in bronchopulmonary dysplasia,pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), cancer, etc. Except for age-related-chronic lung diseases, an increasing number of studies are exploring the role of cellular senescence in developmental chronic lung diseases, which typically originate in childhood and even in the neonatal period. This review provides an overview of cellular senescence and lung diseases from newborns to the elderly, attempting to draw attention to the relationship between cellular senescence and developmental lung diseases.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | Cellular senescence occurs from embryonic development to tissue aging. |
• | Senescent cells exhibit four interdependent hallmarks: permanent cell cycle arrest, macromolecular damage, SASP, and deregulated metabolism. |
• | The senescence of type II cells in the lung is a prophase of most pathologies. |
• | Senolytics and Senomorphics are currently important applications in senescence-associated lung diseases. |
Keywords : Cellular senescence, Bronchopulmonary dysplasia, Age-related-chronic lung diseases, Developmental lung diseases, Senotherapeutics
Esquema
Vol 173
Artículo 116463- avril 2024 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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