Genicular artery embolization for knee osteoarthritis: Results of the LipioJoint-1 trial - 30/03/24
, Charles Querub a, Helena Pereira c, d, Olivier Pellerin a, b, Tom Boeken a, e, Alessandro Di Gaeta a, Marc Al Ahmar a, Marie-Martine Lefevre-Colau f, g, Christelle Nguyen f, h, Camille Daste f, g, Maxime Lacroix i, Jean-Denis Laredo j, Brigitte Sabatier e, k, l, Nicolas Martelli k, m, Gilles Chatellier c, d, Carole Déan a, François Rannou f, h
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Highlights |
• | Genicular artery embolization is a new treatment for knee osteoarthritis. |
• | Genicular artery embolization using an ethiodized oil-based emulsion is safe for the treatment of knee osteoarthritis. |
• | Genicular artery embolization improves pain and knee function for at least three months in patients with knee osteoarthritis. |
Abstract |
Purpose |
The purpose of this study was to evaluate the safety and efficacy of transient genicular artery embolization (GAE) using an ethiodized oil-based emulsion for the treatment of knee osteoarthritis (KOA).
Materials and methods |
This prospective, single-arm, open-label, multicenter, first-in-human cohort trial was registered on ClinicalTrials.gov (NCT04733092). The main inclusion criterion was diagnosis of KOA according to a visual analogue scale (VAS) pain score ≥ 40 mm (score range: 0–100 mm), despite conservative treatment for at least three months. Treatment efficacy was assessed using changes in VAS pain score, Mean Western Ontario & McMaster Universities osteoarthritis (WOMAC) function score (normalized to 100; score ranging from 0 to100) and outcome measures in rheumatoid arthritis clinical trials (OMERACT)-Osteoarthritis Research Society (OARSI) set of responder criteria.
Results |
Twenty-two consecutive participants (13 women; mean age, 66 ± 9 [standard deviation (SD)]) were included and underwent GAE. Emulsion consisted in a mixture of ioversol and ethiodized oil (ratio 1:3, respectively) prepared extemporaneously. The rate of serious adverse events attributed to GAE within one month was 5% (1/22), corresponding to reversible worsening of renal function. Immediate technical success rate was 100%. Mean VAS pain score dropped from 74.4 ± 16.5 (SD) mm at baseline to 37.2 ± 26.7 (SD) mm at three months (P < 0.001). Mean WOMAC function score (normalized to 100: score ranging from 0 to 100) decreased from 57.3 ± 17.1 (SD) at baseline to 33.5 ± 25.9 (SD) at three months (P < 0.001). At three months, 16 out of 22 participants (73%) were considered responders according to the OMERACT-OARSI set of responder criteria, including high improvement in either pain or WOMAC function, or improvement in both pain and WOMAC function.
Conclusion |
GAE using an ethiodized oil-based emulsion is safe and improves pain and function in participants with KOA for at least three months.
El texto completo de este artículo está disponible en PDF.Keywords : Ethiodized oil-based emulsion, Genicular artery embolization, Knee osteoarthritis, Pain management, Transient embolic agent
Abbreviations : GAE, KL, KOA, OARSI, OMERACT, SD, VAS, WOMAC
Esquema
Vol 105 - N° 4
P. 144-150 - avril 2024 Regresar al número
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