Neutrophil extracellular traps and cardiovascular disease: Associations and potential therapeutic approaches - 08/11/24
, Qianfeng Jiang b, ⁎ Abstract |
Cardiovascular disease (CVD) is a significant global health concern, ranking among the top five causes of disability-adjusted life-years (DALY) in 190 countries and territories. Neutrophils, key players in the innate immune system, combat infections by releasing neutrophil extracellular traps (NETs) composed of DNA, histones, elastase, myeloperoxidase, and antimicrobial peptides. This paper explores the relationship between NETs and cardiovascular diseases, focusing on conditions such as heart failure, pulmonary hypertension, atrial fibrillation, and ischemia-reperfusion injury. Particularly, it delves into the impact of NETs on atrial fibrillation and pulmonary hypertension, as well as the role of myeloperoxidase (MPO) and neutrophil elastase (NE) in these diseases. Furthermore, the potential of targeting NETs for the treatment of cardiovascular diseases is discussed.
El texto completo de este artículo está disponible en PDF.Keywords : Neutrophil extracellular traps, Cardiovascular disease, Coronary heart disease, Atrial fibrillation, Heart failure, Pulmonary hypertension, Thrombi
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Vol 180
Artículo 117476- novembre 2024 Regresar al número
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