Anti-androgen Treatments - 24/02/10
, Nathalie Chabbert-Buffet b, Sylvie Salenave c, Véronique Kerlan d, Marie-Béatrice Galand-Portier e
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Abstract |
1. Estrogen plus progestin contraceptives (EPP) are the first-line treatment of moderate hirsutism and acne in women of child bearing age (grade C).
2. CPA, 50mg/day, 20 days out of 28, associated with estrogen is the first-line treatment of “moderate to severe hirsutism” in women of childbearing age (grade C).
3. Spironolactone, given as a contraceptive, can be proposed as a second-line treatment in case of side effects or counter-indications to CPA in moderate to severe hirsutism (grade C) in women of childbearing age. No market authorization in this indication.
4. Flutamide or Finasteride are “only” to be used under the guise of contraception as a “thirdline therapy” in cases of severe hirsutism, the presence of side effects or counter-indications to EPP, CPA 50mg/day or spironolactone (grade C). No market authorization in this indication
5. There is no indication for GnRH analogs as an anti-androgen treatment in women of childbearing age given the current therapeutic alternatives (grade C)
6. Only long-term hair removal treatments can be proposed (grade C): electrolysis or laser hair removal.
El texto completo de este artículo está disponible en PDF.Keywords : Anti-androgen, Estrogen plus progestin contraceptive, Spironolactone, Cyproterone Acetate, Futamide, Finasteride
Esquema
Vol 71 - N° 1
P. 19-24 - février 2010 Regresar al número
Artículo precedente
- Dépistage et prise en charge du déficit en 21-hydroxylase à révélation tardive chez les femmes avec hyperandrogénie
- J. Young, V. Tardy, A. Brac de la Perrière, A. Bachelot, Y. Morel
- Les traitements anti-androgènes
- A. Bachelot, N. Chabbert-Buffet, S. Salenave, V. Kerlan, M.-B. Galand-Portier
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.