HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan - 10/08/11

Doi : 10.1016/j.jpeds.2005.12.025

Jia-Feng Wu, MD ^a,^b,^c, Chen-Hsin Chen, PhD ^a,^b,^c, Rhong-Phong Hsieh ^a,^b,^c, Hsiang-Hung Shih, MD ^a,^b,^c, Yi-Hau Chen, PhD ^a,^b,^c, Chi-Rong Li ^a,^b,^c, Chih-Yao Chiang ^a,^b,^c, Wen-Yi Shau, MD ^a,^b,^c, Yen-Hsuan Ni, MS, PhD ^a,^b,^c, Huey-Ling Chen, MD, PhD ^a,^b,^c, Hong-Yuan Hsu, MD, PhD ^a,^b,^c, Mei-Hwei Chang, MD ^a,^b,^c,^⁎
^a Departments of Pediatrics and Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
^b Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
^c Graduate Institutes of Epidemiology and Clinical Medicine, National Taiwan University, Taipei, Taiwan.

Reprint requests: Mei-Hwei Chang, MD, Department of Pediatrics, National Taiwan University Hospital, 7 Chung-Shan S. Road, Taipei, Taiwan.

Resumen

Objective

To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen (HBeAg).

Study design

In the prospective cohort study, 81 HBeAg-positive children with chronic hepatitis B virus (HBV) infection from 40 unrelated families were recruited and followed-up regularly for a mean period of 17.70 ± 3.23 years. The association between HLA antigen and the age at HBeAg seroconversion was analyzed using Cox regression model with shared frailties under left truncation and right censorship.

Results

HLA-B61 and HLA-DQB1*0503 antigens predicted a higher HBeAg seroconversion rate (relative incidence = 6.17 and 3.22, P = .024 and .017, respectively). Within-family frailty in our sibling cohort study demonstrated a negligible or a low degree of within-family correlation with spontaneous HBeAg seroconversion in each HLA antigen.

Conclusions

HLA class I antigen B61 and class II antigen DQB1*0503 are associated with earlier HBeAg seroconversion in Taiwanese children with chronic HBV infection.

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Abbreviations : CTL, HBeAg, HbsAg, HBV, HLA, MHC

Esquema

General Characteristics of the Study Population

Association Between HLA Markers and Spontaneous HBeAg Seroconversion

Within-Family Frailty of HLA Markers

Discussion

Supported by a grant from the National Science Council, ROC (NSC-87-2314-B002-128) and in part by the Academia Sinica Thematic Project (grant AS91ISS1PP). The authors have no potential, perceived, or real conflict of interest.

Exportación

Vol 148 - N° 5

P. 647 - mai 2006 Regresar al número

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HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan - 10/08/11

Resumen

Objective

Study design

Results

Conclusions

Esquema

Exportación citas

Fichero

Contenido

Mi cuenta

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Declaración CNIL