A Prospective Randomized Study to Determine the Efficacy of Preoperative Topical Levofloxacin in Reducing Conjunctival Bacterial Flora - 21/08/11
, Israel Aguirre-Romo a, Christopher N. Ta b, Julia Dudichum a, Markus Bayrhof a, Volker Klauss a, Anselm Kampik a
Inquiries to Thomas C. Kreutzer, Department of Ophthalmology, University of Munich (LMU), Mathidelstr. 8, 80336 Munich, GermanyResumen |
Purpose |
To compare the efficacy of topical levofloxacin in combination with povidone–iodine irrigation vs povidone–iodine (PVI) alone in reducing conjunctival bacteria.
Design |
Prospective, randomized, controlled trial.
Methods |
One hundred and forty eyes of 140 patients scheduled to undergo intraocular surgery eyes were randomized to either group 1 or 2 (70 each). Whereas group 1 eyes had no prophylactic antibiotic, eyes in group 2 received topical treatment with one drop of 0.5% levofloxacin four times on the day before surgery. Both groups underwent irrigation of the fornices with 1% PVI. Conjunctival swabs were inoculated on solid and broth culture media to determine bacterial growth.
Results |
Of 132 eyes evaluated, baseline culture analysis in thioglycolate demonstrated positive culture results in 55 (84.6%) of 65 eyes from group 1, similar to 55 (82.1%) of 67 eyes in group 2 (P = .697). Before surgery, 57 (87.7%) of 65 eyes in group 1 had positive culture results, compared with 50 (74.6%) of 67 eyes in group 2 (P = .055). After irrigation with PVI, 20 (30.8 %) of 65 eyes in group 1 had positive culture results, compared with only eight (11.9%) of 67 eyes in group 2 (P = .008). After surgery, 15 (23.1%) of 65 eyes in group 1 and six (9.0%) of 67 eyes in group 2 had positive culture results (P = .027).
Conclusions |
Our study shows an enhanced effect of using topical levofloxacin in combination with PVI irrigation to reduce conjunctival bacteria in patients undergoing intraocular surgery.
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Vol 145 - N° 1
P. 136 - janvier 2008 Regresar al número
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