Temporal repolarization lability differences among genotyped patients with the long QT syndrome - 26/08/11

Doi : 10.1016/j.amjcard.2004.07.123

Kenneth Bilchick, MD ^a, Matti Viitasalo, MD ^b, Lasse Oikarinen, MD ^b, Barry Fetics, MSE ^a, Gordon Tomaselli, MD ^a, Heikki Swan, MD ^b, P.äivi J. Laitinen, MSc ^c, Heikki Väänänen, MSc ^d, Kimmo Kontula, MD ^c, Ronald D. Berger, MD, PhD ^a,⁎
^a Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
^b Department of Cardiology
^c Department of Medicine, University of Helsinki, HelsinkiFinland
^d Laboratory of Biomedical Engineering, Helsinki University of Technology, Espoo, Finland

^*Dr. Berger's address is: Carnegie 592, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, Maryland 21287

Resumen

The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (−0.973 ± 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (−0.942 ± 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.

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This work was supported by grants P50 HL52307 and R44 HL61903 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland; the Finnish Foundation for Cardiovascular Research, Helsinki, Finland; the Sigrid Juselius Foundation, Helsinki, Finland; and the Finnish Academy, Helsinki, Finland. Dr. Berger is an established investigator of the American Heart Association, Dallas, Texas, and receives support from the Donald W. Reynolds Foundation, Las Vegas, Nevada.

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Vol 94 - N° 10

P. 1312-1316 - novembre 2004 Regresar al número

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Temporal repolarization lability differences among genotyped patients with the long QT syndrome - 26/08/11

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