The prevalence of both type 1 and type 2 diabetes mellitus (diabetes) is disproportionately high in people with clinically significant depression. Lifestyle programs are recommended for the management of diabetes, but are difficult to implement in practice, particularly for depressed people who are least likely to adhere to healthy lifestyle recommendations. In addition, interventions recommended for the management of depression have limited impact on diabetes outcomes and do not take into account lifestyle risk factors. The aim of this presentation is to inform policy and decision-making on the organization and delivery of effective multidisciplinary care for the management of co-morbid diabetes and depression.