Quantitative PET Imaging Using ¹⁸F Sodium Fluoride in the Assessment of Metabolic Bone Diseases and the Monitoring of Their Response to Therapy - 27/06/12

Doi : 10.1016/j.cpet.2012.04.001

Glen M. Blake, PhD ^a,^⁎ , Musib Siddique, PhD ^a, Michelle L. Frost, PhD ^a, Amelia E.B. Moore, PhD ^a, Ignac Fogelman, MD ^b
^a Osteoporosis Unit, King’s College London, King’s Health Partners, Guy’s Hospital, London SE1 9RT, UK
^b Department of Nuclear Medicine, King’s College London, King’s Health Partners, Guy’s Hospital, London SE1 9RT, UK

Corresponding author. Osteoporosis Research Unit, 1st Floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK.

Resumen

Studies of bone remodeling using bone biopsy and biochemical markers of bone turnover measured in serum and urine are important for investigating how new treatments for osteoporosis affect bone metabolism. Positron emission tomography with ¹⁸F sodium fluoride (¹⁸F NaF PET) for studying bone metabolism complements these conventional methods. Unlike biochemical markers, which measure the integrated response to treatment across the whole skeleton, ¹⁸F NaF PET can distinguish changes occurring at sites of clinically important osteoporotic fractures. Future studies using ¹⁸F NaF PET may illuminate current clinical problems, such as the possible association between long-term treatment with bisphosphonates and atypical fractures of the femur.

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Keywords : Osteoporosis, Paget’s disease, Regional bone turnover, Positron emission tomography, ¹⁸F sodium fluoride, Quantitative imaging, Bone plasma clearance, Standardized uptake value