Les performances cognitives des patients souffrant de troubles psychotiques chroniques sont très souvent altérées. Dans la schizophrénie, quatre patients sur cinq présentent un déficit cognitif selon les normes établies pour la population générale. Par ailleurs, tous les patients subissent une dégradation de leurs performances cognitives par rapport à leur fonctionnement prémorbide, même si celles-ci ne tombent pas toujours en dessous du seuil de normalité. Dans le trouble bipolaire, un patient sur trois présente des troubles cognitifs résiduels en dehors des accès thymiques. Ces considérations doivent conduire à une évaluation neuropsychologique systématique dans la schizophrénie et sur point d’appel dans le trouble bipolaire. La remédiation cognitive est destinée à pallier les conséquences des troubles cognitifs grâce à l’utilisation de méthodes rééducatives. Elle a pour cibles les troubles attentionnels, mnésiques, visuospatiaux et exécutifs, ainsi que les déficits métacognitifs et de cognition sociale. L’action de la remédiation cognitive est destinée à compléter celle des médicaments et de la psychothérapie, qui n’agissent pas au même niveau. Son efficacité a été démontrée par de nombreuses études contrôlées et plusieurs méta-analyses. Quatre programmes de remédiation cognitive validés sont disponibles en langue française (RECOS, CRT, IPT et REHA-COM). Leur mise en œuvre doit s’inscrire dans le cadre d’un projet de soin individualisé associant le cas échéant d’autres outils de réhabilitation permettant de favoriser la réinsertion sociale et/ou professionnelle du patient (entraînement des compétences sociales, psychoéducation, mise en situation professionnelle sans exigence de rentabilité, soutien des familles…). La remédiation cognitive est mise en œuvre après réalisation d’une évaluation neuropsychologique (assortie d’une évaluation clinique et de l’autonomie quotidienne). Elle est généralement destinée à favoriser la réussite d’un projet concret s’inscrivant dans le domaine social (mise en œuvre d’une activité de loisir, autonomisation dans le domaine du logement…) ou professionnel (réinsertion en milieu protégé ou ouvert).

Cognitive disorders (memory, attention, executive functions, metacognition and social cognition disorders) are frequently associated with chronic psychoses particularly schizophrenia. These cognitive disorders greatly compromise the ability of afflicted patients to care for themselves and also significantly affect their social functioning. Furthermore, they manifest with the first psychotic episode. While these symptoms are not as obvious as the defining psychotic symptoms (e.g., hallucinations and delusions), their behavioral consequences can be just as detrimental. Social interactions, work, and leisure activities can all involve basic cognitive activities such as repeating a phone number, integrating interlocutor speech, or organizing one’s own behavior towards defined goals; all the while having to take context into account. The persistence of criticizing delusions or stabilization of verbal hallucinations through treatment are frequently less incapacitating than even moderate cognitive dysfunction. The nature of the cognitive deficit, as revealed by the neuropsychological assessment, can identify the type of functional impairment in a given patient. Deficits in attention and working memory can result in an alteration of occupational functioning. Executive function disorders have an impact on behavior in relationships. Processing speed, attention span and working memory all have an impact on social skills. Cognitive impairment is not necessarily directly linked to functional disability, yet its effects may mediated by other variables such as a patient’s ability to manage a variety of tasks: daily life, social skills, social cognition performances, symptoms, intrinsic motivation and metacognition. Although functional disability is greater for schizophrenia than for bipolar disorder, cognitive impairments are predictive of overall disability for both disorders. Antipsychotics have little beneficial effect on cognitive disorders. While they certainly can alleviate secondary cognitive deficits (e.g., attention disorder resulting from an intense hallucinatory activity), they may also generate iatrogenic cognitive impairments. Cognitive side effects are even more consequential given that antipsychotics are not systematically prescribed with the minimum effective dose; cognitive side effects may be present even in low dosage of antipsychotics when the drug has additional antihistamine or anticholergentic effects. Iatrogenic effects can be aggravated if an antiparkinsonian or a benzodiazepine corrector is associated because of their adverse effects on attention and, additionally, adverse effects on memory abilities for drugs with anticholinergic or GABAergic action. Cognitive remediation was developed to reduce the cognitive deficits or compensate for their consequences by developing alternative skills. The goal of cognitive remediation is concrete intending to promote a professional or social reintegration focusing on an intermediate variable that constitutes itself cognitive performance. To achieve this goal, cognitive remediation targets attention, memory, language and executive processes, as well as social cognition disorders. Improving performances in these areas appears to have a positive impact on functional deficits that affect daily life. Cognitive remediation is not an alternative to psychotropic treatments and/or psychotherapy, but is intended to supplement their effects. These three methods of treatment act at different levels. In practice, cognitive remediation provides an improvement in cognitive functioning, either directly by retraining the impaired functions, or indirectly through the functions developed in order to compensate. Taking into account the patient’s vulnerability aids in reducing his handicap and encouraging recovery, through validation of the various situations he or she faces in daily life. Cognitive remediation is an essential therapeutic tool that can promote psychosocial rehabilitation in a patient with chronic psychotic disorder. Ideally it should be associated with other rehabilitating tools, like social skills training, psychoeducation, role playing (using a non-threatening situation), and family support. Cognitive remediation is indicated for patients whose clinical condition is stable and for whom medication is reduced to the minimum effective dose. In the ideal scenario, it is advisable to treat only the primary symptoms linked to cognitive disorders (rather than the secondary ones) or iatrogenic cognitive impairments. In some cases, the patients under care of are still symptomatic or suffering from iatrogenic cognitive effects. Should some symptoms remain under antipsychotic medication, cognitive remediation is fully justified when the benefit-risk ratio has been clearly determined. It is, however, necessary that patient condition remain stable and that some practical benefits can be attained.