Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus - 18/09/13
, Viswanathan Mohan b, Prasad Thakurdesai bAbstract |
Background |
Plant-derived polysaccharides such as galactomannans (GAL) have very interesting and useful applications in the biomedical and biopharmaceutical field. GAL from fenugreek (Trigonella foenum graecum L.) seeds has been shown to have promising but inconsistent anti-hyperglycemic activity due to variable composition.
Aim |
We have isolated and characterized low molecular weight GAL fraction from fenugreek seeds (LMWGAL-TF) and evaluated its anti-hyperglycemic potential.
Materials and methods |
LMWGAL-TF was isolated, well characterized (HPLC and LC-MS) and evaluated for anti-hyperglycemic activity after acute and subacute oral treatment in doses of 50, 100 and 200mg/kg in alloxan-induced hyperglycemia in mice.
Results |
The isolated LMWGAL-TF was of 91.5% purity with low molecular weight. LMWGAL-TF showed dose-dependent anti-hyperglycemic activity against alloxan-induced hyperglycemia without body weight gain, and protected mice pancreas from alloxan-induced histological changes.
Conclusions |
LMWGAL-TF showed promising and dose-dependent anti-hyperglycemic effects in animal model of DM.
El texto completo de este artículo está disponible en PDF.Keywords : Fenugreek, Galactomannans, Low molecular weight soluble fibre, Anti-hyperglycemic
Esquema
Vol 3 - N° 3
P. 145-151 - juillet 2013 Regresar al número
Artículo precedente
- Normobaric hyperoxia (HO) preconditioning induces durable and effective neuroprotection against cerebral ischemia and mGluRII expression
- Samane Nasrniya, Mohammad Reza Bigdeli
- Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and scavenging ROS and NO
- Li Yuan, Xiaomeng Ren, Yuchen Wu, Jing Wang, Haifang Xiao, Xuebo Liu
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?