Inhibition of preadipocyte differentiation and lipid accumulation by 7-O-galloyl-d-sedoheptulose treatment in 3T3-L1 adipocytes - 07/12/13
Abstract |
In this study, we investigated the effect of 7-O-galloyl-d-sedoheptulose (GS) on adipocyte differentiation in 3T3-L1 cells. GS significantly suppressed 3T3-L1 differentiation. The activation of adenosine monophosphate-activated protein kinase (AMPK) was demonstrated by measuring phosphorylation. In addition, GS down-regulated the adipogenesis-related protein expression of the sterol regulatory element-binding protein 1c. GS significantly reduced the protein expression of the peroxisome proliferator-activated receptor γ and of the CCAAT/enhancer-binding protein α, two key transcription factors in adipogenesis. These findings indicate that GS exerts anti-adipogenic activity via AMPK activation and may act to prevent obesity.
El texto completo de este artículo está disponible en PDF.Keywords : 7-O-Galloyl-d-sedoheptulose, 3T3-L1 cell, Adipogenesis, AMPK, SREBP1c, PPARγ, C/EBPα
Esquema
Vol 3 - N° 4
P. 319-324 - octobre 2013 Regresar al número
Artículo precedente
- Protective role of coenzyme Q10, riboflavin, niacin, selenium (CoRNS) and Emblica officinalis on cardiac abnormalities in experimental atherosclerosis
- Umapathi Indumathi, Karvannan Kanchana, Panchanatham Sachdanandam
- Design, synthesis and biological evaluation of some isatin-linked chalcones as novel anti-breast cancer agents: A molecular hybridization approach
- Chandrabose Karthikeyan, Viswas Raja Solomon, Hoyun Lee, Piyush Trivedi
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?