Polymorphous Light Eruption : Clinic Aspects and Pathogenesis - 01/06/14

Doi : 10.1016/j.det.2014.03.012

Alexandra Gruber-Wackernagel, MD ^a, Scott N. Byrne, PhD ^b, Peter Wolf, MD ^a,^⁎
^a Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, Graz A-8036, Austria
^b Cellular Photoimmunology Group, Infectious Diseases and Immunology, Department of Dermatology, Sydney Medical School, Royal Prince Alfred Hospital, The University of Sydney, 676, Blackburn Building D06, Darlington, New South Wales 2006, Australia

^∗Corresponding author.

Resumen

Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to a photoantigen have been suggested as key factors in the disease. Molecular and immunologic disturbances associated with disease pathogenesis include a failure of skin infiltration by neutrophils and other regulatory immune cells on UVR exposure linked to a disturbed cytokine microenvironment. Standard management is based on prevention.

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Keywords : Polymorphous light eruption, Polymorphic, Photoantigen, Immune suppression, Cytokines, Chemotaxis, Photoprotection, Skin cancer

Esquema

	Funding Sources: P. Wolf was supported by the Oesterreichische Nationalbank Anniversary Fund project no. 13279 and FWF Austrian Science Fund no. KLI 132-B00.
	Conflict of Interest: None.