Índice

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·Continuing Medical Education Calendar

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• Reviews and feature articles

  • ·A Special Thank-You to Our Reviewers

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  • ·Non–IgE-mediated anaphylaxis

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    Antonella Cianferoni

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  • ·Non–IgE-mediated anaphylaxis

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  • ·Mechanisms of human drug-induced anaphylaxis

    Página :1133-1142

    Pierre Bruhns, Sylvie Chollet-Martin

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  • ·Principles, potential, and limitations of ex vivo basophil activation by flow cytometry in allergology: A narrative review

    Página :1143-1153

    Didier G. Ebo, Chris H. Bridts, Christel H. Mertens, Vito Sabato

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  • ·The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds

    Página :1154-1163

    Stephen C. Dreskin, Stef J. Koppelman, Sandra Andorf, Kari C. Nadeau, Anjeli Kalra, Werner Braun, Surendra S. Negi, Xueni Chen, Catherine H. Schein

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  • ·Component-resolved diagnostics in pet allergy: Current perspectives and future directions

    Página :1164-1173

    Ann-Marie M. Schoos, Bright I. Nwaru, Magnus P. Borres

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  • ·Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

    Página :1174

    Yael Renert-Yuval, Jacob P. Thyssen, Robert Bissonnette, Thomas Bieber, Kenji Kabashima, DirkJan Hijnen, Emma Guttman-Yassky

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• The Editors' choice

  • ·The Editors’ Choice

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• News beyond our pages

  • ·News Beyond Our Pages

    Página :1202-1203

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Non-IgE adverse reactions to biologics

    Página :1204-1206

    Leticia de las Vecillas, Mariana Castells

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  • ·Omalizumab in “non–IgE-mediated” diseases

    Página :1207-1208

    R. Sharon Chinthrajah, Stephen J. Galli

     
  • ·The role of IgG subclasses and platelets in experimental anaphylaxis

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    Ophélie Godon, Béatrice Hechler, Friederike Jönsson

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• Editorials

  • ·Diagnosing allergic bronchopulmonary aspergillosis/mycosis: Return to lost horizons

    Página :1212-1214

    Richard B. Moss

    
  • ·NSAID hypersensitivity—the unwitting accomplice in the growing opiate epidemic

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    Andrew A. White, Riccardo Asero

     

• COVID-19

  • ·Efficacy of early anti-inflammatory treatment with high doses of intravenous anakinra with or without glucocorticoids in patients with severe COVID-19 pneumonia

    Página :1217-1225

    Emanuele Pontali, Stefano Volpi, Alessio Signori, Giancarlo Antonucci, Marco Castellaneta, Davide Buzzi, Amedeo Montale, Marta Bustaffa, Alessia Angelelli, Roberta Caorsi, Elisa Giambruno, Nicoletta Bobbio, Marcello Feasi, Ilaria Gueli, Francesca Tricerri, Francesca Calautti, Elio Castagnola, Andrea Moscatelli, Gian Andrea Rollandi, Angelo Ravelli, Giovanni Cassola, Maria Pia Sormani, Marco Gattorno

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  • ·SARS-CoV-2 infection and viral load are associated with the upper respiratory tract microbiome

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    Christian Rosas-Salazar, Kyle S. Kimura, Meghan H. Shilts, Britton A. Strickland, Michael H. Freeman, Bronson C. Wessinger, Veerain Gupta, Hunter M. Brown, Seesandra V. Rajagopala, Justin H. Turner, Suman R. Das

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• Asthma and lower airway disease

  • ·Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze

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    Mengdi Lu, Augusto A. Litonjua, George T. O’Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani

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  • ·Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling

    Página :1242-1260

    Yeon Duk Woo, Jaemoon Koh, Jae Sung Ko, Sehui Kim, Kyeong Cheon Jung, Yoon Kyung Jeon, Hye Young Kim, Ho Lee, Chang Woo Lee, Doo Hyun Chung

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  • ·New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation

    Página :1261

    Koichiro Asano, Akira Hebisawa, Takashi Ishiguro, Noboru Takayanagi, Yasuhiko Nakamura, Junko Suzuki, Naoki Okada, Jun Tanaka, Yuma Fukutomi, Shigeharu Ueki, Koichi Fukunaga, Satoshi Konno, Hiroto Matsuse, Katsuhiko Kamei, Masami Taniguchi, Terufumi Shimoda, Tsuyoshi Oguma, Japan ABPM Research Program

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  • ·Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease

    Página :1269-1280

    Bogdan Jakiela, Jerzy Soja, Krzysztof Sladek, Marek Przybyszowski, Hanna Plutecka, Anna Gielicz, Ana Rebane, Grazyna Bochenek

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  • ·IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity

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    Emily Howard, Gavin Lewis, Lauriane Galle-Treger, Benjamin P. Hurrell, Doumet Georges Helou, Pedram Shafiei-Jahani, Jacob D. Painter, German Aleman Muench, Pejman Soroosh, Omid Akbari

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  • ·Type 2–high asthma is associated with a specific indoor mycobiome and microbiome

    Página :1296

    Louise-Eva Vandenborght, Raphaël Enaud, Charlotte Urien, Noémie Coron, Pierre-Olivier Girodet, Stéphanie Ferreira, Patrick Berger, Laurence Delhaes

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• Rhinitis, sinusitis, and ocular allergy

  • ·Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps

    Página :1306-1317

    Aiko I. Klingler, Whitney W. Stevens, Bruce K. Tan, Anju T. Peters, Julie A. Poposki, Leslie C. Grammer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato

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  • ·Inflammatory heterogeneity in aspirin-exacerbated respiratory disease

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    William C. Scott, Katherine N. Cahill, Ginger L. Milne, Ping Li, Quanhu Sheng, Li Ching Huang, Spencer Dennis, Jacob Snyder, Ashley M. Bauer, Rakesh K. Chandra, Naweed I. Chowdhury, Justin H. Turner

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• Atopic dermatitis and inflammatory skin disease

  • ·Atopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity

    Página :1329-1340

    Angeline S.L. Tay, Chenhao Li, Tannistha Nandi, Kern Rei Chng, Anand Kumar Andiappan, Vijaya Saradhi Mettu, Camille de Cevins, Aarthi Ravikrishnan, Charles-Antoine Dutertre, X.F. Colin C. Wong, Amanda Hui Qi Ng, Sri Anusha Matta, Florent Ginhoux, Olaf Rötzschke, Fook Tim Chew, Mark B.Y. Tang, Yik Weng Yew, Niranjan Nagarajan, John E.A. Common

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  • ·Astrocytic STAT3 activation and chronic itch require IP₃R1/TRPC-dependent Ca²⁺ signals in mice

    Página :1341-1353

    Miho Shiratori-Hayashi, Chiharu Yamaguchi, Kazushi Eguchi, Yuto Shiraishi, Keita Kohno, Katsuhiko Mikoshiba, Kazuhide Inoue, Motohiro Nishida, Makoto Tsuda

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  • ·Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33

    Página :1354

    Arwa Al Kindi, Helen Williams, Kenshiro Matsuda, Abdullah M. Alkahtani, Charis Saville, Hayley Bennett, Yasmine Alshammari, Soo Y. Tan, Catherine O’Neill, Akane Tanaka, Hiroshi Matsuda, Peter D. Arkwright, Joanne L. Pennock

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  • ·Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities

    Página :1369-1380

    Helen He, Ester Del Duca, Aisleen Diaz, Hyun Je Kim, Jesús Gay-Mimbrera, Ning Zhang, Jianni Wu, Jessica Beaziz, Yeriel Estrada, James G. Krueger, Ana B. Pavel, Juan Ruano, Emma Guttman-Yassky

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• Food allergy and gastrointestinal disease

  • ·Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis

    Página :1381-1392

    Kelly Bruton, Paul Spill, Shabana Vohra, Owen Baribeau, Saba Manzoor, Siyon Gadkar, Malcolm Davidson, Tina D. Walker, Joshua F.E. Koenig, Yosef Ellenbogen, Alexandra Florescu, Jianping Wen, Derek K. Chu, Susan Waserman, Rodrigo Jiménez-Saiz, Slava Epelman, Clinton Robbins, Manel Jordana

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  • ·?-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG₄

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    Jeffrey M. Wilson, Behnam Keshavarz, Hayley R. James, Maya K.C. Retterer, Alexander J. Schuyler, Alice Knoedler, Lisa J. Workman, Lucy Ng’ang’a, Martha E. Chico, Eva Rönmark, Peter W. Heymann, Matthew S. Perzanowski, Thomas A.E. Platts-Mills, Philip J. Cooper

    Resumen Resumen Esquema Esquema  

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians

    Página :1402-1412

    Chuang-Wei Wang, Wichittra Tassaneeyakul, Chun-Bing Chen, Wei-Ti Chen, Yu-Chuan Teng, Cheng-Yang Huang, Chonlaphat Sukasem, Chun-Wei Lu, Yun-Shien Lee, Siew-Eng Choon, Nontaya Nakkam, Rosaline Chung-Yee Hui, Yen-Hua Huang, Ya-Ching Chang, Yang Yu-Wei Lin, Chee-Jen Chang, Tsu-Man Chiu, Wasun Chantratita, Parinya Konyoung, Chaw-Ning Lee, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Warayuwadee Amornpinyo, Niwat Saksit, Pawinee Rerknimitr, Yu Huei Huang, Shang-Hung Lin, Chao-Kai Hsu, Cheng-Chi Chan, Yu-Jr Lin, Shuen-Iu Hung, Wen-Hung Chung, Taiwan/Asian Severe Cutaneous Adverse Reaction Consortium

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  • ·Impact of reported NSAID “allergies” on opioid use disorder in back pain

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    Lily Li, Yuchiao Chang, Shuang Song, Elena Losina, Karen H. Costenbader, Tanya M. Laidlaw

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• Biologics and immunotherapy

  • ·ARGX-117, a therapeutic complement inhibiting antibody targeting C2

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    Inge Van de Walle, Karen Silence, Kevin Budding, Liesbeth Van de Ven, Kim Dijkxhoorn, Elisabeth de Zeeuw, Cafer Yildiz, Sofie Gabriels, Jean-Michel Percier, Johanna Wildemann, Jan Meeldijk, Peter J. Simons, Louis Boon, Linda Cox, Rob Holgate, Rolf Urbanus, Henny G. Otten, Jeanette H.W. Leusen, Christophe Blanchetot, Hans de Haard, C. Erik Hack, Peter Boross

    Resumen Resumen Esquema Esquema  

• Mechanisms of allergy/immunology

  • ·Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model

    Página :1430-1441

    Paul Engeroff, Kevin Plattner, Federico Storni, Franziska Thoms, Kayluz Frias Boligan, Lukas Muerner, Alexander Eggel, Stephan von Gunten, Martin F. Bachmann, Monique Vogel

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  • ·Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8

    Página :1442-1452

    Anabel Gonzalez-Gil, T. August Li, Ryan N. Porell, Steve M. Fernandes, Haley E. Tarbox, Hyun Sil Lee, Kazuhiro Aoki, Michael Tiemeyer, Jean Kim, Ronald L. Schnaar

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  • ·Integrated genetic and epigenetic analyses uncover MSI2 association with allergic inflammation

    Página :1453-1463

    Kyung Won Kim, Sang-Cheol Park, Hyung-Ju Cho, Haerin Jang, Jaehyun Park, Hyo Sup Shim, Eun Gyul Kim, Mi Na Kim, Jung Yeon Hong, Yoon Hee Kim, Sanghun Lee, Scott T. Weiss, Chang-Hoon Kim, Sungho Won, Myung Hyun Sohn

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  • ·CaMKII oxidation regulates cockroach allergen–induced mitophagy in asthma

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    Yan Zhang, Danh C. Do, Xinyue Hu, Ji Wang, Yilin Zhao, Sumita Mishra, Xin Zhang, Mei Wan, Peisong Gao

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• Translational and clinical immunology

  • ·Basophils and IgE contribute to mixed connective tissue disease development

    Página :1478

    Yasmine Lamri, Shamila Vibhushan, Emeline Pacreau, Erwan Boedec, Fanny Saidoune, Arnaud Mailleux, Bruno Crestani, Ulrich Blank, Marc Benhamou, Thomas Papo, Eric Daugas, Karim Sacré, Nicolas Charles

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• Brief reports

  • ·Increased group 2 innate lymphoid cells in peripheral blood of adults with mastocytosis

    Página :1490

    Esmee K. van der Ploeg, Maud A.W. Hermans, Vincent H.J. van der Velden, Willem A. Dik, Paul L.A. van Daele, Ralph Stadhouders

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  • ·Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology

    Página :1497

    Matthew P. Giannetti, Cem Akin, Raied Hufdhi, Matthew J. Hamilton, Emily Weller, Bjorn van Anrooij, Jonathan J. Lyons, Jason L. Hornick, Geraldine Pinkus, Mariana Castells, Olga Pozdnyakova

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• Letters to the Editor

  • ·Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes

    Página :1502

    Pia Gattinger, Urska Bidovec-Stojkovic, Mihaela Zidarn, Peter Korosec, Rudolf Valenta, Irene Mittermann

     
  • ·CXXC5 variant in an immunodeficient patient with a progressive loss of hematopoietic cells

    Página :1504

    Hemant R. Joshi, Harry R. Hill, Julie Asch, Rebecca L. Margraf, Emily Coonrod, Jacob Durtschi, Qin Zhou, Xiao He, Karl V. Voelkerding, Attila Kumánovics

     
  • ·IL-10–producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy

    Página :1507

    Tadech Boonpiyathad, Pongsakokorn Tantilipikorn, Kiat Ruxrungtham, Panitan Pradubpongsa, Wat Mitthamsiri, Aurélie Piedvache, Pattarawat Thantiworasit, Sunee Sirivichayakul, Alain Jacquet, Narissara Suratannon, Pantipa Chatchatee, Naho Morisaki, Hirohisa Saito, Atik Sangasapaviriya, Kenji Matsumoto, Hideaki Morita

     
  • ·Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells

    Página :1510

    Anand Kumar Andiappan, Kia Joo Puan, Bernett Lee, Poh Tuang Yeow, Nurhashikin Yusof, Simon Kebede Merid, Dilip Kumar, Josephine Lum, Shihui Foo, Geraldine Koh, Michael Poidinger, Francesca Zolezzi, eQTLGen Consortium, BIOS Consortium, De Yun Wang, Erik Melén, Olaf Rotzschke

     
  • ·ILC3-derived acetylcholine promotes protease-driven allergic lung pathology

    Página :1513

    Matthew Darby, Luke B. Roberts, Claire Mackowiak, Alisha Chetty, Sasha Tinelli, Corinna Schnoeller, Valerie Quesniaux, Sylvie Berrard, Dieudonnée Togbe, Murray E. Selkirk, Bernhard Ryffel, William G.C. Horsnell

     
  • ·Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3⁺ regulatory T cells

    Página :1517-1521

    Hye-Ji Kang, Gi-Cheon Kim, Choong-Gu Lee, Sunhee Park, Garima Sharma, Ravi Verma, Sin-Hyeog Im, Ho-Keun Kwon

      
  • ·Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with ?-melanocyte–stimulating hormone

    Página :1521

    Svea Kleiner, Urda Rüdrich, Manuela Gehring, Karin Loser, Britta Eiz-Vesper, Gaetan A. Noubissi Nzeteu, Nikolaos Patsinakidis, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap

     

• Correspondence

  • ·Addressing anxiety and avoidance in food-induced anaphylaxis

    Página :1524

    Eyal Shemesh, Scott H. Sicherer

    
  • ·Reply

    Página :1524-1525

    Katherine Dahlsgaard, Megan O. Lewis, Jonathan M. Spergel

    

• Retraction notice

  • ·Retraction notice

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  • ·Retraction notice

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• Corrigenda

  • ·Corrigenda

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  • ·Corrigenda

    Página :1528-1530