Impact of disease-modifying treatments on humoral response after COVID-19 vaccination: A mirror of the response after SARS-CoV-2 infection - 02/12/21
, L. Kremer a, b, M. Fleury a, L. Lanotte a, b, N. Collongues a, b, J. de Seze a, b
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Abstract |
Objective |
To analyze the humoral response after COVID-19 vaccination in patients with multiple sclerosis (MS) according to disease-modifying treatments (DMTs) and in comparison with the humoral response after SARS-CoV-2 infection.
Methods |
We included 28 MS patients with serological results after COVID-19 vaccination (Pfizer-BioNTech or Moderna ARNm) and 61 MS patients with serological results after COVID-19 (COVID-19 group) among patients followed up at the MS Center of Strasbourg, France, between January and April 2021. The primary endpoint was the IgG index according to DMTs (anti-CD20 mAb, sphingosine 1-phosphate receptor [S1PR] modulator and other treatments) and COVID-19 vaccine or COVID-19 groups.
Results |
In the vaccinated MS patients, the median IgG index was lower in patients treated with anti-CD20 mAb and in patients treated with S1PR modulator compared to patients receiving other or no DMTs (4.80 [1.58–28.6], 16.5 [16.3–48.5], 1116 [434–1747] and 1272 [658–1886], respectively, P<0.001). Similar results were found for MS patients after COVID-19.
Conclusions |
Patients with MS and treated with S1PR modulators or anti-CD20 mAb had a reduced humoral response after COVID-19 vaccine.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Multiple sclerosis, COVID-19, Vaccine, Humoral response, Antibody
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Vol 177 - N° 10
P. 1237-1240 - dicembre 2021 Ritorno al numero
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