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Telemedicine and type 1 diabetes: Is technology per se sufficient to improve glycaemic control? - 07/02/14

Doi : 10.1016/j.diabet.2013.09.001 
S. Franc a, b, , S. Borot c, O. Ronsin d, J.-L. Quesada e, D. Dardari b, C. Fagour f, E. Renard g, A.-M. Leguerrier h, C. Vigeral i, F. Moreau j, P. Winiszewski k, A. Vambergue l, H. Mosnier-Pudar m, L. Kessler j, S. Reffet n, B. Guerci o, L. Millot p, S. Halimi q, r, C. Thivolet n, P.-Y. Benhamou q, A. Penfornis c, G. Charpentier a, b, H. Hanaire s
a Department of Diabetes, Sud-Francilien Hospital, Corbeil-Essonnes, France 
b Centre d’Études et de Recherches pour l’Intensification du Traitement du Diabète (CERITD), Corbeil-Essonnes, France 
c Department of Endocrinology-Metabolism and Diabetology-Nutrition, Jean-Minjoz Hospital, Besançon, France 
d Department of Diabetes, Sainte-Marguerite University Hospital, Marseille, France 
e Department of Biostatistics, CIC–Inserm, University Hospital, Grenoble, France 
f Department of Endocrinology, University Hospital Pessac, Pessac, France 
g Department of Endocrinology, University Hospital, Montpellier, France 
h Department of Endocrinology, University Hospital, Rennes, France 
i Department of Diabetes, Hôtel-Dieu University Hospital, Paris, France 
j Department of Endocrinology, University Hospital, Strasbourg, France 
k Department of Endocrinology, Belfort Hospital, Belfort, France 
l Clinique Marc Linquette, Department of Endocrinology and Diabetology, Lille, France 
m Department of Diabetes, Cochin Hospital, Paris, France 
n Department of Endocrinology, Édouard-Herriot Hospital, Lyon, France 
o Diabetology, Nutrition, Metabolic disorders, Brabois Hospital and Center of Clinical Investigation ILCV, University Hospital, Nancy, France 
p Department of Endocrinology, Bellevue Hospital, Saint-Étienne, France 
q Department of Endocrinology, Diabetology, Nutrition University Hospital, Grenoble, France 
r University J Fourier 1, Grenoble, France 
s Department of Diabetes, Rangueil University Hospital, Toulouse, France 

Corresponding author. Department of Diabetes, Sud-Francilien Hospital, 116, boulevard Jean-Jaurès, 91100 Corbeil-Essonnes, France. Tel.: +33 1 61 69 30 86; fax: +33 1 61 69 76 27.

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Abstract

Aim

In the TELEDIAB-1 study, the Diabeo system (a smartphone coupled to a website) improved HbA1c by 0.9% vs controls in patients with chronic, poorly controlled type 1 diabetes. The system provided two main functions: automated advice on the insulin doses required; and remote monitoring by teleconsultation. The question is: how much did each function contribute to the improvement in HbA1c?

Methods

Each patient received a smartphone with an insulin dose advisor (IDA) and with (G3 group) or without (G2 group) the telemonitoring/teleconsultation function. Patients were classified as “high users” if the proportion of “informed” meals using the IDA exceeded 67% (median) and as “low users” if not. Also analyzed was the respective impact of the IDA function and teleconsultations on the final HbA1c levels.

Results

Among the high users, the proportion of informed meals remained stable from baseline to the end of the study 6months later (from 78.1±21.5% to 73.8±25.1%; P=0.107), but decreased in the low users (from 36.6±29.4% to 26.7±28.4%; P=0.005). As expected, HbA1c improved in high users from 8.7% [range: 8.3–9.2%] to 8.2% [range: 7.8–8.7%] in patients with (n=26) vs without (n=30) the benefit of telemonitoring/teleconsultation (−0.49±0.60% vs −0.52±0.73%, respectively; P=0.879). However, although HbA1c also improved in low users from 9.0% [8.5–10.1] to 8.5% [7.9–9.6], those receiving support via teleconsultation tended to show greater improvement than the others (−0.93±0.97 vs −0.46±1.05, respectively; P=0.084).

Conclusion

The Diabeo system improved glycaemic control in both high and low users who avidly used the IDA function, while the greatest improvement was seen in the low users who had the motivational support of teleconsultations.

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Keywords : Telemedicine, Telemonitoring, Decision support software, Type 1 diabetes

Abbreviations : BG, CSII, FBG, MII, PPBG


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