Alexithymia in multiple sclerosis: Clinical and radiological correlations - 12/08/20

Doi : 10.1016/j.neurol.2020.06.008

N. Capet ^a,⁎ , H. Joly ^a , C. Suply ^b , L. Mondot ^a , M. Cohen ^a , C. Lebrun-Frenay ^a
^a MS unit research Nice Cote D’azur university (UR2CA), CHU de Nice, Pasteur 2 university hospital, 30, voie Romaine, 06002 Nice, France
^b Department of neurology, Pasteur 2 university hospital, 30, voie Romaine, 06002 Nice, France

^⁎Corresponding author. MS unit research Nice Cote D’azur university (UR2CA), CHU de Nice, Pasteur 2 university hospital, 30, voie Romaine, 06002 Nice, France.MS unit research Nice Cote D’azur university (UR2CA), CHU de Nice, Pasteur 2 university hospital30, voie RomaineNice06002France

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Abstract

Background

Alexithymia, meaning no words for emotions is a common problem that could affect up to 53% of patients in multiple sclerosis (MS).

Objectives

To determine the frequency of alexithymia in MS and investigate MS-related abnormalities in structural magnetic resonance imaging (MRI) and their associations with fatigue and cognitive functions.

Methods

Ninety-five patients at all stages of the disease were examined: 21 with clinically isolated syndromes (CIS), 30 with relapsing-remitting MS (RRMS), 21 with primary (PP) and 23 with secondary progressive MS (SPMS). Alexithymia was measured with the Toronto alexithymia scale (TAS-20) and correlated to cognitive functions, depression, and fatigue. Voxel-based morphometry MRI was analyzed to determine lesion load, cerebral and regional atrophy.

Results

Fifty-seven of patients had alexithymia with no significant difference between the clinical phenotypes. Alexithymic patients differed from non-alexithymic patients on fatigue, depression and information processing speed. Compared to non-alexithymic patients, alexithymic patients had decreased volumes of cerebral and cerebellar white matter and there was a significant relationship between alexithymia and decreased brainstem, thalamic and corpus callosum volume.

Conclusion

Regardless of the phenotype of MS, alexithymia is associated with atrophy of cerebral and cerebellar white matter, brainstem, corpus callosum, and thalami.

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Keywords : Multiple sclerosis, Alexithymia, Cerebral atrophy, Social cognition, Fatigue