In vivo clinical and radiological effects of platelet-rich plasma on interstitial supraspinatus lesion - 26/11/15
Résumé |
Background |
Rotator cuff tear (RCT) is a frequent condition of clinical relevance that can be managed with symptomatic conservative treatment, but must often be surgically managed. Biological components like platelet-rich plasma (L-PRP) could represent an alternative curative treatment for interstitial RCT.
Hypothesis |
Ultrasound guided L-PRP injection in supraspinatus interstitial RCT would induce radiological healing and improve symptoms.
Methods |
A prospective case series was performed in order to assess the effect of L-PRP infiltration into supraspinatus interstitial RCTs. Primary outcome was tear size evolution determined by magnetic resonance imaging arthrogram (MRA) before and 6 months after L-PRP infiltration. Secondary outcomes were Constant score, SANE score, and Pain Visual Analogue Scale (VAS) evolution after L-PRP infiltration.
Results |
Twenty-five patients were included into this study. Tear volume diminution was statistically significant (P=.007), and a>50% tear volume diminution was observed in 15 patients. A statistically significant amelioration of Constant score (P<.001), SANE score (P=.001), and VAS (P<.001) was observed. In 21 patients, Constant score amelioration reached the minimal clinically important difference of 10.4 points.
Conclusion |
We observed a statistically significant and clinically relevant effect on RCT size and clinical parameters after L-PRP infiltration. In clinical practice, such an important amelioration of supraspinatus interstitial RCT with conservative management is uncommon, therefore intratendinous L-PRP infiltrations could have been beneficial. This encouraging result should pave the way to future randomized studies in order to formally determinate whether L-PRP infiltrations could be an alternative to surgical treatment of interstitial RCT.
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Vol 101 - N° 8S
P. e23 - décembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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