A review of FGF signaling in palate development - 29/05/18

Doi : 10.1016/j.biopha.2018.04.026

Mengjia Weng ^a,^{^{1
Both authors contributed equally to this manuscript.}}, Zhengxi Chen ^a,^{^{1
Both authors contributed equally to this manuscript.}}, Qian Xiao ^b, Ruomei Li ^a, Zhenqi Chen ^a,^⁎
^a Department of Orthodontics, Shanghai Ninth People’s Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China
^b Department of Pharmacology, School of Medicine, Yale University, New Haven, USA

^⁎Corresponding author at: Department of Orthodontics, College of Stomatology, Shanghai Ninth People’s Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai, 200011, China.Department of OrthodonticsShanghai Ninth People’s HospitalSchool of StomatologyShanghai Key Laboratory of StomatologyShanghai Jiao Tong UniversityShanghaiChina

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Highlights

•	FGF signaling is critical throughout the process of palatogenesis especially in the outgrowth of palatal shelves.
•	The important roles of interaction between Fgf family and other signaling pathways during palatogenesis.
•	Nicotine, chlorcyclizine, TCDD, dexamethasone and retinoids could induce cleft palate via FGF signaling and other factors.

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Abstract

The fibroblast growth factors (FGFs) play a critical role during palatogenesis by mediating a variety of cellular responses. Extensive epidemiological and genetic studies over several decades in humans have revealed members of the FGF family function as candidate genes for syndromic and nonsyndromic cleft lip and cleft palate. The findings that FGFs signaling work delicately in the development of palate have been confirmed in mice carrying targeted mutations. Here we try to review recent progress toward a detailed understanding of FGF signaling including FGF7, FGF8, FGF9, FGF10, FGF18 and their receptors FGFR1, FGFR2 in palate development studies and discuss how they interact with other factors on the basis of animal studies regarding cleft palate.

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Keywords : FGF signaling, Cleft palate, Palatogenesis, Teratogens

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Vol 103

P. 240-247 - juillet 2018 Retour au numéro

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A review of FGF signaling in palate development - 29/05/18

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