The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a - 29/05/18

Doi : 10.1016/j.biopha.2018.01.105

Luyi Chai ^a,^⁎ , Yongping Yuan ^b, Chao Chen ^c, Jianbo Zhou ^a, Yanyan Wu ^a
^a Department of Stomatology, Ningbo Yinzhou People’s Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo 315040, Zhejiang, PR China
^b Department of Stomatology Technology, Ningbo Colloge Of Health Sciences, Ningbo 315040, Zhejiang, PR China
^c Head and Neck Surgery Department, Zhejiang Cancer Hospital, HangZhou 310022, Zhejiang, PR China

^⁎Corresponding author at: Department of Stomatology, Ningbo Yinzhou People’s Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo 315040, Zhejiang, PR China.Department of StomatologyNingbo Yinzhou People’s Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University)NingboZhejiang315040PR China

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Abstract

Recently, increasing evidence has indicated that lncRNAs may play a critical role in the progression of oral cancer (OC). However, whether lncRNA-ANRIL is involved in the tumorigenesis of OC remains undetermined. In the present study, ANRIL showed significantly higher, while miR-125a showed lower, expression in OC tissues and sera than in normal controls. MTT, colony formation, flow cytometry analysis, wound-healing, transwell and mice xenograft model assays were used to detect the proliferation, migration, and invasion of ARNIL-overexpressing HB56 cells and ARNIL-knockdown CAL27 cells. The results showed that cell proliferation, migration, and invasion were significantly increased by ARNIL overexpression and decreased by ARNIL silencing in oral cancer cells. Furthermore, we found a negative correlation between ARNIL and miR-125a, and ARNIL acts as a miRNA-sponge by directly interacting with miR-125a.

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Keywords : lncRNA ANRIL, miR-125a, Oral cancer, Proliferation, Migration, Invasion

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Vol 103

P. 38-45 - juillet 2018 Retour au numéro

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The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a - 29/05/18

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