Type 1 diabetes: Through the lens of human genome and metagenome interplay - 11/06/18
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| pages | 11 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | T1D results from the interplay between environmental and genetic factors. |
• | Uncovering the epigenetic/genetic factors appears to be extremely challenging. |
• | Data strongly suggest the impact of gut microbiota on the pathogenesis of T1D. |
• | Targeting the microbiota T1D seems to be an attractive therapeutic approach. |
Abstract |
Diabetes is a genetic- and epigenetic-related disease from which a large population worldwide suffers. Some genetic factors along with various mutations related to the immune system for disease mechanism(s) have contrastively been determined. However, sometimes mechanisms have not been fully managed for the clarification of the initiation and/or progression of diseases to help patients. In the recent years, due to familiarity with the role of gut microbiota in the health, it has been found that the changes of the microbial balance in the industrialized societies can cause a battery of modern diseases, for which we have no specific definition of how they emerge. This work aims to explore the relationship between the human gut microbiota and the immune system along with their possible role in avoiding/emerging of type 1 diabetes (T1D) accompanied with the relation between genome and metagenome and their imbalance in causing T1D. Moreover, it provides novel view on how to balance the intestinal microbiota by lifestyle to hinder the mechanisms leading to T1D.
Le texte complet de cet article est disponible en PDF.Keywords : Diabetes, Immune system, Microbiota, Probiotic, Mucosal immunity
Plan
Vol 104
P. 332-342 - août 2018 Retour au numéro
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