Combination of Ginsenoside H dripping pills and cyclophosphamide improve paraneoplastic syndrome and inhibit postoperative recurrence via the reversion of Th1/Th2 shift - 13/11/18
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Iconographies | 8 |
Vidéos | 0 |
Autres | 0 |
Highlights |
• | The positive-margin resection model differs to primary tumor in dynamics and TME. |
• | GH alone had no potency in tumor inhibition but can prominent prolong survival. |
• | GH had a synergy in tumor inhibition and QOL improvement when combined with CTX. |
• | The underlying mechanisms were related to reverse Th1/Th2 shift caused by CTX. |
Abstract |
Non-small-cell lung cancer (NSCLC) is recognized as the most common malignant disease worldwide and combination treatment is recommended as its first line therapy. As a Ph2 clinical product, Ginsenoside H dripping pills (GH) is proposed as an adjuvant of chemotherapy. In the present study, we utilized a postoperative model to evaluate the efficacy of GH on the functions of anti-recurrence and improvement of life quality when combined with chemotherapeutic drug cyclophosphamide (CTX). Specifically, the anti-recurrence effect was evaluated by tumor inhibiting rate and the improvement of life quality was evaluated by the remission of splenomegaly and emaciation. The underlying mechanisms were explored via quantitative real time-PCR, Elisa and IHC staining. Results showed that GH had a synergy when combined with CTX against tumor recurrence, significantly improved the life quality of postoperative patients via remitting splenomegaly and emaciation. H&E staining showed that GH could increase the number of splenic T cells, which were inhibited after CTX administration. Furthermore, the reversion of Th1/Th2 shift, which had been verified by different methods, may account for one of the mechanisms of the synergy. All these results indicated Ginsenoside H dripping pills as a promising adjuvant for postoperative chemotherapy of NSCLC.
Le texte complet de cet article est disponible en PDF.Abbreviation : VP-16, GEM, PTX, NVB, DDP, i. g., i. p., HIF, TORC1, EMT, MET
Keywords : Ginsenoside H dripping pills, NSCLC, Postoperative, Recurrence, Splenomegaly, Th1/Th2 shift
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Vol 108
P. 865-875 - décembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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