Liupao tea extract alleviates diabetes mellitus and modulates gut microbiota in rats induced by streptozotocin and high-fat, high-sugar diet - 18/09/19
, Baiping Ma a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Liupao tea improved diabetes mellitus in rats induced by streptozotocin and high-fat, high-sugar diet. |
• | Liupao tea showed beneficial effect on modulating gut microbiota composition. |
• | SCFA-producing bacteria were up-regulated and SCFAs were increased in feces. |
• | Twenty-nine key phylotypes were significantly correlated with diabetic indices. |
Abstract |
Liupao tea, a popular dark tea, exhibited anti-diabetic activity in Chinese tea culture. However, the bioavailability of the main active components is low. Therefore, the relationship between the anti-diabetic activity and the modulation of gut microbiota was investigated in this study for the first time. Liupao tea extract (LTE) could significantly alleviate hyperglycemia, insulin-resistance, and plasma lipid profiles. The hypoglycemic effect of high-dose LTE was comparable to that of metformin. Importantly, LTE exhibited beneficial effect on modulating the diabetic-induced disorder of gut microbiota, such as increasing Bacteroidetes/Firmicutes ratio and up-regulating putative short-chain fatty acid (SCFA)-producing bacteria, including Prevotella and Bacteroides. Moreover, 29 key phylotypes were significantly correlated with at least one diabetic index. In conclusion, LTE could be developed into an anti-diabetic functional beverage and its beneficial effects is likely to be associated with the prebiotic effects for increasing the level of SCFAs and the relative abundance of SCFA-producing bacteria.
Le texte complet de cet article est disponible en PDF.Abbreviations : CMC-Na, FBG, FINS, GC, GPR, HFHSD, HOMA-IR, HPLC, LTE, LPS, OGTT, OTUs, SCFA, STZ, TC, TG, 2h-PBG, UPLC-Q-TOF/MS
Keywords : Dark tea, Liupao tea, Gut microbiota, Diabetes mellitus, Prevotella, Short-chain fatty acid
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Vol 118
Article 109262- octobre 2019 Retour au numéro
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