Accuracy of a CT density threshold enhancement to identify pancreatic parenchyma necrosis in acute pancreatitis during the first week - 30/04/22
, Raphael Le Guen a, Inès Ben Rhouma a, Ayoub Guerrab a, Nadeem Beydoun a, Brice Bergougnoux a, Pierre Ingrand c, Guillaume Herpe a
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Highlights |
• | An enhancement threshold value <30 Hounsfield units on portal phase CT images yields 90.9% sensitivity and 94.3% specificity for the diagnosis of necrotizing pancreatitis vs. interstitial edematous pancreatitis during the first week. |
• | Use of this threshold is associated with excellent interobserver reproducibility (ICC = 0.978). |
• | No post-contrast attenuation threshold was identified for the diagnosis of peripancreatic fat necrosis. |
Abstract |
Purpose |
The purpose of this study was to identify attenuation threshold value on computed tomography (CT) that allowed discriminating between interstitial edematous pancreatitis (IEP) and necrotizing pancreatitis (NP) in patients with acute pancreatitis during the first week of the disease and evaluate interobserver reproducibility for the diagnosis of acute pancreatitis category.
Materials and methods |
Patients with acute pancreatitis who underwent CT examination of the abdomen between March 2015 and December 2019 were retrospectively included. Actual diagnosis of IEP or NP was based on final clinical report, follow-up evaluation, and complications. Six regions of interest were manually placed in the pancreatic gland and peripancreatic fat, and differences in CT attenuation values before contrast injection and during the portal venous phase of enhancement were computed. Performance in the diagnosis of AP category was evaluated using receiver operating characteristic analysis. Interobserver agreement was estimated by the intraclass correlation coefficient (ICC) and Bland Altman analysis was used to estimate reproducibility between pairs of observers.
Results |
Sixty-six patients with NP (46 men, 20 women; mean age, 55 ± 17 [SD] years; age range: 20-89 years) and 70 patients with IEP (39 men, 31 women; mean age, 54 ± 18 [SD] years; age range: 21–87 years) were included. An enhancement value less than 30 Hounsfield units (HU) in the pancreatic gland during the portal phase compared to non-contrast phase, yielded 90.9% sensitivity (60/66; 95% CI: 81.3–96.6), 94.3% specificity (66/70; 95% CI: 86.0–98.4) and an area under curve of 0.958 (95% CI: 0.919–0.996) for the diagnosis of NP versus IEP. Interobserver reproducibility for pancreas enhancement was good using Bland Altman plot and ICC was excellent for pancreatic gland analysis (ICC 0.978; 95% CI: 0.961–0.988) but poor or moderate (ICC ≤0.634) regarding peripancreatic fat necrosis.
Conclusion |
By using a pancreas enhancement threshold value of 30 HU, CT is accurate and reproducible for the diagnosis of NP during the first week of the disease.
Le texte complet de cet article est disponible en PDF.Keywords : Acute necrotizing pancreatitis, Multidetector row CT (MDCT), X-ray computed tomography, Threshold CT value, Revised Atlanta Classification
Plan
Vol 103 - N° 5
P. 266-272 - mai 2022 Retour au numéro
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