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Consequences of preoperative cardiac stress testing—A cohort study - 09/09/23

Doi : 10.1016/j.jclinane.2023.111158 
Matthew A. Pappas, MD, MPH a, b, c, , Andrew D. Auerbach, MD, MPH d, Michael W. Kattan, PhD e, Eugene H. Blackstone, MD f, Michael B. Rothberg, MD, MPH a, Daniel I. Sessler, MD c, g
a Center for Value-based Care Research, Cleveland Clinic, Cleveland, OH, United States of America 
b Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH, United States of America 
c Outcomes Research Consortium, Cleveland, OH, United States of America 
d Department of Hospital Medicine, University of California, San Francisco, CA, United States of America 
e Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America 
f Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, United States of America 
g Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, United States of America 

Corresponding author at: 216.444.9565, 9500 Euclid Ave., Mail Stop G-10, Cleveland, OH 44195, United States of America.216.444.95659500 Euclid Ave.Mail Stop G-10ClevelandOH44195United States of America

Abstract

Objective

To understand the consequences of functional cardiac stress testing among patients considering noncardiac nonophthalmologic surgery.

Design

A retrospective cohort study of 118,552 patients who made 159,795 visits to a dedicated preoperative risk assessment and optimization clinic between 2008 and 2018.

Setting

A large integrated health system.

Patients

Patients who visited a dedicated preoperative risk assessment and optimization clinic before noncardiac nonophthalmologic surgery.

Measurements

To assess changes to care delivered, we measured the probability of completing additional cardiac testing, cardiac surgery, or noncardiac surgery. To assess outcomes, we measured time-to-mortality and total one-year mortality.

Main results

In causal inference models, preoperative stress testing was associated with increased likelihood of coronary angiography (relative risk: 8.6, 95% CI 6.1–12.1), increased likelihood of percutaneous coronary intervention (RR: 4.1, 95% CI: 1.8–9.2), increased likelihood of cardiac surgery (RR: 6.8, 95% CI 4.9–9.4), decreased likelihood of noncardiac surgery (RR: 0.77, 95% CI 0.75–0.79), and delayed noncardiac surgery for patients completing noncardiac surgery (mean 28.3 days, 95% CI: 23.1–33.6). The base rate of downstream cardiac testing was low, and absolute risk increases were small. Stress testing was associated with higher mortality in unadjusted analysis but was not associated with mortality in causal inference analyses.

Conclusions

Preoperative cardiac stress testing likely induces coronary angiography and cardiac interventions while decreasing use of noncardiac surgery and delaying surgery for patients who ultimately proceed to noncardiac surgery. Despite changes to processes of care, our results do not support a causal relationship between stress testing and postoperative mortality. Analyses of care cascades should consider care that is avoided or substituted in addition to care that is induced.

Le texte complet de cet article est disponible en PDF.

Highlights

Cardiac stress testing probably leads to higher rates of cardiac testing and interventions (a “care cascade”)
However, stress testing also decreases the likelihood that patients will complete surgery
Stress testing probably does not change mortality in the short- or long-term
Health datasets rarely capture care that is considered but not completed; many care cascades might instead be substitutions

Le texte complet de cet article est disponible en PDF.

Keywords : Preoperative period, Perioperative care, Diagnostic techniques, Cardiovascular, Outcome and process assessment


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Vol 90

Article 111158- novembre 2023 Retour au numéro
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