Biomarkers of acute kidney injury: From discovery to the future of clinical practice - 25/04/24
Abstract |
Purpose of this review
Acute kidney injury (AKI) is a complex syndrome whose development is associated with an increased morbidity and mortality. Recent studies show that this syndrome is a common complication in critically ill and surgical patients the trajectory of which may differ. As AKI can be induced by different triggers, it is complex and therefore challenging to manage patients with AKI. This review strives to provide a brief historical perspective on AKI, elucidate recent developments in diagnosing and managing AKI, and show the current usage of novel biomarkers in both clinical routine and research. In addition, we provide a perspective on potential future developments and their impact of AKI understanding and management.
Recent findings/developments
Recent studies show the merits of stress and damage biomarkers, highlighting limitations of the current KDIGO definition that only uses the functional biomarkers serum creatinine and urine output. The use of novel biomarkers led to the introduction of the concept of “subclinical AKI”. This new classification may allow a more distinct management of affected or at risk patients. Ongoing studies, such as BigpAK-2 and PrevProgAKI, investigate the implementation of biomarker-guided interventions in clinical practice and may demonstrate an improvement in patients' outcome.
Summary
The ongoing scientific efforts surrounding AKI have deepened our understanding of the syndrome prompting an expansion of existing concepts. A future integration of stress and damage biomarkers in AKI management, may lead to an individualized therapy in this area.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Acute kidney injury (AKI) is a common complication in critically ill and surgical patients. |
• | The KDIGO definition that uses the functional biomarkers serum creatinine and urine output has limitations. |
• | Novel biomarkers are able to detect a “subclinical AKI”. |
• | An integration of stress and damage biomarkers in AKI management, may lead to an individualized therapy in this area. |
Keywords : Acute kidney injury, KDIGO criteria, Biomarkers of AKI, Subclinical AKI
Plan
Vol 95
Article 111458- août 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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