Mycophenolate mofetil–associated enterocolitis - 17/08/11
Doi : 10.1016/j.gie.2005.09.047
| Commentary MMF inhibits purine synthesis and is used to prevent solid organ transplant rejection and as a possible therapy for refractory inflammatory bowel disease. Dose-related diarrhea is the most common side effect, attributable to enterocolitis. Diagnosis is by failure to demonstrate another cause (eg, CMV) and by symptomatic improvement upon decreasing or stopping MMF. A biopsy specimen is characteristic and resembles that of graft vs host disease: prominent crypt cell apoptosis, increased neuroendocrine cells, cellular atypia, and glandular distortion. Postulated mechanisms include direct toxicity or an “innocent bystander” phenomenon because of an MMF–altered bowel immune microenvironment. Lawrence J. Brandt, MD Associate Editor of Focal Points |
© 2006
American Society for Gastrointestinal Endoscopy. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 63 - N° 4
P. 707-708 - avril 2006 Retour au numéro
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