Preterm low birth weight and maternal periodontal status: a meta-analysis - 22/08/11
, Michel Sixou, PhD, HDR 
Reprints: Jean-Noël Vergnes, Dental School, Department of epidemiology, 3, Chemin des Maraichers 31400 Toulouse, France.Résumé |
Objective |
This study was undertaken to assess the effect of maternal periodontal disease on preterm delivery and/or birth of low-weight infants.
Study design |
We conducted a meta-analytic review of 5 medical databases (MEDLINE, EMBASE, LILACS, BIOSIS and PASCAL) for human observational studies linking preterm delivery and/or birth of low-weight infants to maternal periodontal disease. The MOOSE guidelines for meta-analysis of observational studies were followed.
Results |
The literature search revealed 17 articles that met the inclusion criteria. Seven thousand one hundred fifty-one women participated in the studies, 1056 of whom delivered a preterm and/or low birthweight infant. The overall odds ratio was 2.83 (95% CI: 1.95-4.10, P < .0001). This pooled value needed to be interpreted cautiously because there appeared to be a clear trend for the better quality studies to be of lower association strength.
Conclusion |
These findings indicate a likely association, but it needs to be confirmed by large, well-designed, multicenter trials.
Le texte complet de cet article est disponible en PDF.Key words : low birthweight, meta-analysis, periodontal disease, preterm birth, risk factor
Plan
| Cite this article as: Vergnes J-N, Sixou M. Preterm low birth weight and maternal periodontal status: A meta-analysis. Am J Obstet Gynecol 2007;196:135.e1-135.e7. |
Vol 196 - N° 2
P. 135.e1-135.e7 - février 2007 Retour au numéro
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