Psychosis-proneness correlates with expression levels of dopaminergic genes - 14/06/14
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Abstract |
Psychosis-proneness or schizotypy is a personality organisation mirroring individual risk for schizophrenia-development. Believed to be a fully dimensional construct sharing considerable geno- and phenotypal variance with clinical schizophrenia, it has become an increasingly promising tool for basic psychosis-research. Although many studies show genetic commonalities between schizotypy and schizophrenia, changes in regulation of gene expression have never been examined in schizotypy before. We therefore extracted RNA from the blood, a valid surrogate for brain tissue, of a large sample of 67 healthy male volunteers and correlated the activities of all genes relevant for dopaminergic neurotransmission with the positive schizotypy-scale of the O-LIFE. We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level. Considering the advantages of this method, we suggest that it be applied more often in fundamental psychosis-research.
Le texte complet de cet article est disponible en PDF.Keywords : Schizophrenia and psychosis, Molecular biology, Psychosis proneness, Schizotypy, Gene expression, Endophenotype
Plan
☆ | These data were, in part, presented at the 2013-meeting of the International Society for the Study of Individual Differences. |
Vol 29 - N° 5
P. 304-306 - juin 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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