Two pediatric cases of multisystem inflammatory-like syndrome following COVID-19 vaccination - 17/11/22

Doi : 10.1016/j.arcped.2022.08.018

C. Collignon ^a,^⁎ , C. Frachette ^b,^c,^k,^l, D. Callot ^d, Y. Pinhas ^e,^f, P. Bataille ^f,^g, B. Bader-Meunier ^f,^h, L. Chouchana ^d, M.-L. Frémond ^f,^h, Z. Belhadjer ⁱ, M. Oualha ^a,^f, F. Moulin ^a, E. Javouhey ^c,^j, A. Belot ^k,^l,^b,^c, S. Renolleau ^a,^f
^a Pediatric Intensive Care Unit, APHP University Hospital Necker-Enfants malades, Paris, France
^b Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France
^c Faculty of Medicine, University of Lyon, 69100 Villeurbanne, France
^d Regional Center of Pharmacovigilance, Department of Pharmacology, Cochin Hospital, AP-HP. Centre – Université de Paris, Paris, France
^e Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants-Malades University Hospital, APHP, Centre-Université de Paris, Paris, France
^f Université de Paris, Paris, France
^g Department of Dermatology, Reference Centre for Genodermatoses and Rare Skin Disease (MAGEC), Hopital Universitaire Necker-Enfants Malades, APHP, Paris, France
^h Department of Pediatric Immunology and Rheumatology, AP-HP, Necker Hospital, Paris, France
ⁱ M3C-Necker Enfants Malades, AP-HP, Paris, France
^j Pediatric Intensive Care Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France
^k National Referee Centre for Rheumatic and Autoimmune and Systemic Diseases in Children (RAISE), 69677 Bron, France
^l Lyon Immunopathology Federation LIFE, Hospices Civils de Lyon, 69002 Lyon, France

^⁎Corresponding author at: Pediatric Intensive Care Unit, Necker-Enfants malades University Hospital, 149 rue de Sèvres, 75015 Paris, France.Pediatric Intensive Care UnitNecker-Enfants malades University Hospital149 rue de SèvresParis75015France

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a novel post-infectious disease occurring in the context of SARS-CoV2 infection. COVID-19 vaccines have been authorized since December 2020, and adverse events including myocarditis have been reported following vaccination. We describe the cases of two pediatric patients presenting with clinical and laboratory features suggestive of MIS-C a few days after receiving their first dose of the Pfizer BNT162b2 vaccine. The outcome was favorable for both patients (after corticosteroid and immunoglobulin administration for one patient). These cases suggest an association between the COVID-19 vaccine and the occurrence of MIS-C.

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Keywords : Multisystem inflammatory syndrome in children, COVID-19 vaccine, Pediatric intensive care unit, Side effect, Case report

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Vol 29 - N° 8

P. 620-623 - novembre 2022 Regresar al número

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Two pediatric cases of multisystem inflammatory-like syndrome following COVID-19 vaccination - 17/11/22

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