Recently, a new platform of abdominal access has emerged in human and veterinary laparoscopy called single-port surgery. The single-port platform enables all laparoscopic instruments, including the telescope, to pass individually through the same abdominal incision. Recently, there have been several published reports documenting the efficacy and safety of single-port procedures in veterinary patients. This article discusses the common single-port devices and instrumentation as well as procedures now routinely offered in veterinary minimally invasive surgery.