Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats - 02/06/16
, Vasudevan Gopalakrishnan b, Jone A. Stanley b, c, Senthilkumar Krishnamoorthy b, Ramachandran Ilangovan b, Velliyur K. Gopalakrishnan a, Narasimhan Srinivasan b, d, ⁎ Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 8 |
| Iconografías | 8 |
| Vídeos | 0 |
| Otros | 0 |
Abstract |
The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats.
Methods |
Twenty four female adult rats, 90 days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n = 6) were sham operated and Group-II rats were bilaterally ovariectomized (n = 18) and treated with C. quadrangularis for sixty days (100 mg/ kg body weight and 250 mg/kg body weight). After sixty days, the rats were killed, femora were dissected out, minced and homogenized in Tris-HCl buffer (pH 7.4) and the supernatant was collected and used for biochemical assays.
Results |
Ovariectomy registered a decrease (p<0.05) in the activities of SOD, GPx, GST, ALP, collagen content and increased (p< 0.05) the activities of TRAP and lipid peroxidation. Simultaneous administration of C. quadrangularis maintained the enzyme activities in ovariectomized rats.
Conclusion |
C. quadrangularis , a natural herb may be used to treat the estrogen deficiency/menopause onset and ovariectomy induced oxidative stress.
El texto completo de este artículo está disponible en PDF.Abbreviations : BMD, OVX, SOD, CAT, GPx, GST, H 2 O 2 , MDA, ROS, RAW, ICI 182, 780, TRAP, ALP, RANKL
Keywords : Ovariectomy, Oxidative stress, C. quadrangularis , Bone loss
Esquema
Vol 81
P. 416-423 - juillet 2016 Regresar al número
Artículo precedente
- Clozapine and olanzapine are better antioxidants than haloperidol, quetiapine, risperidone and ziprasidone in in vitro models
- Francis Fregonesi Brinholi, Carine Coneglian de Farias, Kamila Landucci Bonifácio, Luciana Higachi, Rúbia Casagrande, Estefânia Gastaldello Moreira, Décio Sabbatini Barbosa
- Anti-inflammatory effect of taurocholate on TNBS-induced ulcerative colitis in mice
- Yang Yang, Jiao He, Yuan Suo, Le Lv, Jingjing Wang, Chuanchuan Huo, Zongwei Zheng, Ziye Wang, Jing Li, Wenji Sun, Yongmin Zhang
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?