Ameliorative effect of vitamin E and selenium against oxidative stress induced by sodium azide in liver, kidney, testis and heart of male mice - 08/06/17
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Abstract |
The study purported to define the effects of daily administration of vitamin E (Vit E) and selenium (Se) on antioxidant enzyme activity in mice treated with high doses of sodium azide (SA). Male mice were randomly split into nine groups. Groups 1, 2 and 3 were injected daily with saline, Vit E, and Se, respectively, while groups 4, 5 and 6 administrated with different doses of SA (low, medium and high, respectively). The mice in groups 7, 8 and 9 received 100mg/kg Vit E, 17.5mg/kg Se, and a combination of Vit E and Se, respectively before the SA-treatment. Hepatic, renal, testis and heart, antioxidant enzymes as well as levels of lipid peroxidation and total antioxidant capacity levels were determined. Vit E alone affected on the antioxidant parameters of the examined tissues. Se had a preventive effect on the decrease of antioxidant parameters caused by SA and improved the diminished activities of all of them. The study demonstrates that a high dose of SA may alter the effects of normal level antioxidant/oxidative status of male mice and that Se is effective in reducing the SA-damage. Se acts as a synergistic agent with the effect of Vit E in various damaged caused by SA.
El texto completo de este artículo está disponible en PDF.Keywords : Sodium azide, Vitamin E, Selenium, Liver, Kidney, Testis, Heart, Antioxidant enzymes
Esquema
Vol 91
P. 602-610 - juillet 2017 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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