Cell-based skin substitutes accelerate regeneration of extensive burn wounds in rats - 15/09/17
Abstract |
Background |
This study investigated the effects of amniotic membrane combined with adipose-derived stem cells or fetal fibroblasts on regenerating extensive burns in rats.
Methods |
Third degree burns of 1100–1800 mm2 were induced on 32 Sprague-Dawley rats. Burned sites were excised and randomly covered with Vaseline gauze (control), human amniotic membrane (HAM), human fetal fibroblasts seeded on HAM (HAM-FF), or human adipose-derived stem cells seeded on HAM (HAM-ASC), and followed by wound closure and histological assessments.
Results |
Wound closure rates of HAM-FF, HAM-ASC, HAM and control groups at seven and 14 days after the treatment were 42.2% and 81.9%, 41.9% and 81.7%, 33.5% and 74.2%, and 16.5% and 69.7%, respectively. Wounds of HAM-FF, HAM-ASC, HAM and control groups were closed on 40, 40, 50 and 60 days after the treatment, respectively (P < 0.05). Histological assessments revealed lower inflammatory cell infiltration in HAM-ASC and HAM-FF groups.
Conclusions |
Cell-based engineered skin substitutes seem to accelerate wound regeneration, especially within the first 14 days.
El texto completo de este artículo está disponible en PDF.Keywords : Burn, Stem cell, Tissue engineering, Wound healing
Esquema
Vol 214 - N° 4
P. 762-769 - octobre 2017 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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