High mortality rate associated with KPC-producing Enterobacter cloacae in a Brazilian hospital - 23/12/17
Doi : 10.1016/j.ajic.2017.07.011
Kesia Esther da Silva, MSc a, Tháigor Rezek Varella, MD a, Graciela Mendonça dos Santos Bet, MSc a, b, Cecília Godoy Carvalhaes, PhD c, Maisa Estopa Correa, MSc a, Nathalie Gaebler Vasconcelos, MSc a, b, Julio Croda, PhD a, b, d, Ana Cristina Gales, PhD c, Simone Simionatto, PhD a, *, 1 
a Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados—UFGD, Dourados, Mato Grosso do Sul, Brazil
b Hospital Universitário de Dourados, Universidade Federal da Grande Dourados—UFGD, Dourados, Mato Grosso do Sul, Brazil
c Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo—UNIFESP, São Paulo, Brazil
d Fundação Osvaldo Cruz, Campo Grande, Mato Grosso do Sul, Brazil
*Address correspondence to Simone Simionatto, PhD, Rodovia Dourados—Itahum km 12, Cidade Universitária, CEP: 79804970, Dourados, Mato Grosso do Sul, Brazil. (S. Simionatto).Rodovia Dourados—Itahum km 12Cidade UniversitáriaCEP: 79804970DouradosMato Grosso do SulBrazil
Highlights |
• | Patients diagnosed with KPC-producing Enterobacter cloacae showed a high mortality rate (41.8%). |
• | Infection was associated with a previous use of antibiotics and urinary catheter. |
• | Patients with a urinary catheter have 51-fold risk of developing infection. |
• | The genotyping analysis showed a clonal dissemination in the intensive care unit. |
• | Infection control measures and use of stricter antibiotic policies are required. |
Abstract |
We describe a clonal dissemination of KPC-producing Enterobacter cloacae in a Brazilian hospital. Patients diagnosed with theses isolates showed high mortality rate (41.8%) and were associated with previous use of antibiotics and urinary catheterization. Therefore, infection control measures and use of stricter antibiotic policies are required to control the spread of these organisms.
El texto completo de este artículo está disponible en PDF.Key Words : Antibiotic resistance, β-lactamases, Enterobacteriaceae
| Funding/support: Supported by the Brazilian National Research Council (CNPq grants 480949/2013-1) and Support Foundation for the Development of Education, Science and Technology in the State of Mato Grosso do Sul (FUNDECT grant nos. 0077/12 and 0212/12). K.E.S. received scholarship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, and M.E.C. received funding from FUNDECT. A.C.G. is a researcher from the National Council for Science and Technological Development (CNPq), Ministry of Science and Technology, Brazil (process no. 307816/2009-5). |
|
| Conflicts of interest: None to report. |
© 2018
Association for Professionals in Infection Control and Epidemiology, Inc.. Publicado por Elsevier Masson SAS. Todos los derechos reservados.
Vol 46 - N° 1
P. 108-110 - janvier 2018 Regresar al número
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