Brain Metastases - 01/08/18

Doi : 10.1016/j.ncl.2018.04.010

Ayal A. Aizer, MD, MHS ^a,^b, Eudocia Q. Lee, MD, MPH ^b,^c,^d,^⁎
^a Department of Radiation Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
^b Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
^c Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
^d Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA

^∗Corresponding author. Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215.Center for Neuro-OncologyDana-Farber Cancer Institute450 Brookline AvenueBostonMA02215

Resumen

Brain metastases from solid tumors are associated with increased morbidity and mortality. Standard treatment is local therapy with surgery and/or radiation therapy although there is increasing interest in systemic therapies that can control both intracranial and extracranial disease. We review the most recent data for local therapy and systemic therapy options. Active areas of research within radiation oncology include hippocampal sparing whole brain radiation therapy and stereotactic approaches for patients with more than 4 brain metastases. Newer targeted therapies with better central nervous system penetration and immunotherapies have demonstrated promising results in clinical trials of patients with brain metastases.

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Keywords : Brain metastases, Breast cancer, Lung cancer, Melanoma, Whole brain radiation, Stereotactic radiosurgery