Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance - 04/11/18
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
Artículo gratuito.
Conéctese para beneficiarse!
Abstract |
Aims |
To assess circulating fetuin-B concentrations in subjects with different degrees of glucose tolerance and to analyze the association of fetuin-B concentrations with insulin resistance and the first phase of glucose-stimulated insulin secretion.
Methods |
Plasma fetuin-B concentrations were analyzed in 149 subjects with normal glucose tolerance (NGT, n=54), impaired glucose regulation (preDM, n=42) and newly diagnosed type-2 diabetes mellitus (nT2DM, n=53). Intravenous glucose tolerance tests (IVGTTs) and biochemical parameters were also assessed in all participants.
Results |
Plasma fetuin-B concentrations were significantly higher in nT2DM patients compared with NGT and preDM subjects (both P<0.001) and positively correlated with FPG, 2hPG, HOMA-IR, HbA1c, hsCRP, FINS and TG (P<0.05), but negatively correlated with AIR, AUC, GDI and fasting Belfiore index (P<0.01). After adjusting for age and gender, all correlations remained statistically significant (P<0.05). Multivariate logistic regression analysis revealed that plasma fetuin-B concentrations were significantly correlated with nT2DM after controlling for age, gender, BMI, WHR, blood pressure and lipid profiles.
Conclusion |
Patients with nT2DM have significantly higher concentrations of plasma fetuin-B compared with NGT subjects and plasma fetuin-B is strongly associated with glucose and lipid metabolism, chronic inflammation and first-phase glucose-stimulated insulin secretion and insulin resistance.
El texto completo de este artículo está disponible en PDF.Keywords : Fetuin-B, Impaired glucose regulation, Insulin resistance, Type-2 diabetes mellitus
Esquema
Vol 44 - N° 6
P. 488-492 - décembre 2018 Regresar al número
Artículo precedente
- Consuming snacks mid-afternoon compared with just after lunch improves mean amplitude of glycaemic excursions in patients with type 2 diabetes: A randomized crossover clinical trial
- S. Imai, S. Kajiyama, Y. Hashimoto, A. Nitta, T. Miyawaki, S. Matsumoto, N. Ozasa, M. Tanaka, S. Kajiyama, M. Fukui
- SGLT2 inhibitors and incretin agents: Associations with alanine aminotransferase activity in type 2 diabetes
- H.S. Bajaj, R.E. Brown, L. Bhullar, N. Sohi, S. Kalra, R. Aronson
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.