Cutaneous Metastasis - 28/11/18

Doi : 10.1016/j.hoc.2018.08.008

John D. Strickley, BS ^a,^b, Alfred Bennett Jenson, MS, MD ^a, Jae Yeon Jung, MD, PhD ^a,^c,^d,^⁎
^a James Graham Brown Cancer Center, University of Louisville School of Medicine, 529 S. Jackson Street, Louisville, KY 40202, USA
^b Department of Dermatology, Center for Cancer Immunology and Cutaneous Biology Research Center, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
^c Division of Dermatology, University of Louisville School of Medicine, 3810 Springhurst Boulevard, Suite. 200, Louisville, KY 40241, USA
^d Onco-Dermatology Program, Norton Cancer Institute, 676 South Floyd Street, Suite 200, Louisville, KY 40202, USA

^∗Corresponding author. 676 South Floyd Street, Suite 200, Louisville, KY 40202.676 South Floyd StreetSuite 200LouisvilleKY40202

Resumen

Although rare, cutaneous metastases portend a poor prognosis and are often an indicator of widespread disease. Breast cancer and melanoma are the most common types of cancer that are associated with spread to and within the skin; however, other malignancies, such as lung, colon, head and neck, and hematologic, have been described with a degree of relative frequency. A variety of clinical appearances and syndromes of cutaneous metastases are presented and described in this article. Possible treatment options, including skin-directed therapies and immunotherapies, are also discussed.

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Keywords : Metastasis, Cutaneous metastases, Skin, Melanoma, Breast cancer, Dermatology, Oncology

Esquema

Colorectal Cancer Figure and Sister Mary Joseph Nodule

Head and Neck Cancer

Hematologic malignancy

General approach to therapy

Summary

Disclosure Statement: J.Y. Jung - Regeneron: Principal investigator, Consultant; Merck: Principal investigator; Iderra: Principal investigator; Adgero: Consultant; Amgen: Consultant, Speaker.