Bone Pathology for Hematopathologists - 27/07/19

Doi : 10.1016/j.path.2019.03.007

Deniz Peker, MD ^{^{1
These authors contributed equally.}}, Shi Wei, MD, PhD ^{^{1
These authors contributed equally.}}, Gene P. Siegal, MD, PhD ^⁎
Department of Pathology, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL 35249, USA

^∗Corresponding author.

Abstract

Bone pathology can be challenging because the skeleton is a living tissue prone to developing a diverse array of inflammatory, metabolic, genetic, reactive, circulatory, and neoplastic abnormalities. Several areas of bone pathology are particularly difficult or problematic for hematopathologists given the close resemblance of some hematologic entities to primary/metastatic bone lesions; examples include plasmacytic disorders versus osteoblastic tumors and lymphoma/leukemia versus round cell tumors of bone. This article provides a conceptual and practical overview of selective bone disorders commonly encountered in the differential diagnosis of hematologic diseases.

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Keywords : Plasmacytoma, Osteosarcoma, Osteomyelitis, Langerhans cell histiocytosis, Mastocytosis, Rosai-Dorfman disease, Ewing sarcoma, Mesenchymal chondrosarcoma

Esquema

Disclosure: Dr. Siegal has received partial support from the Haley’s Hope Memorial Support Fund for Osteosarcoma Research at the University of Alabama at Birmingham and the Thomas Logan RAID Fund for Ewing’s Sarcoma Research.