Anticoagulation-related nephropathy might just be the most common diagnosis you've never heard of. It was formerly known as warfarin-induced nephropathy, until it was observed with numerous other anticoagulants and broadened to anticoagulation-related nephropathy. It is a potentially devastating disorder with serious and life-changing consequences if not recognized and diagnosed swiftly. As the clinician is faced with new acute renal failure, it is important to appreciate those factors that place patients at greater risk of anticoagulation-related nephropathy: conditions such as underlying chronic kidney disease patients and supratherapeutic international normalized ratio. Through greater understanding of this common yet under-recognized condition, we become better equipped to diagnose and prognosticate potential patients. Currently, there are no specific guidelines to follow regarding anticoagulation-related nephropathy identification and management; however, it is an entity that is important to remember, especially given the number of patients requiring anticoagulation for numerous conditions.