Mr. Kim et al. Reply - 24/09/19

Doi : 10.1016/j.jaac.2019.04.024

Hyunsik Kim, MA ^⁎ , Ashley Greene, MA, Nicholas R. Eaton, PhD, Matthew Lerner, PhD, Kenneth Gadow, PhD
Stony Brook University, NY

^∗Correspondence to Hyunsik Kim, MA, Department of Psychology, Psychology B Building, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794Department of PsychologyPsychology B BuildingStony Brook University100 Nicolls RdStony BrookNY11794

Resumen

We write to respond to an erudite letter to the editor by Zachary J. Williams.¹ that extended analyses presented in our recent publication² investigating the latent structure of autism phenotypic symptoms. The letter by Williams reported results of a bifactor analysis using the standardized loadings and interfactor correlations derived from a Schmid−Leiman orthogonalization of the optimal correlated factor model that we identified. Williams examined the relative contributions of the general and three specific autism symptom factors (ie, social interaction [SI], communication [COM], and restrictive and repetitive behavior [RRB]) to the autism symptom indicators. Those analyses indicated that the majority of autism spectrum disorder (ASD) symptom covariation could be explained by a single general autism factor, whereas the three specific autism symptom factors accounted for minimal covariation among indicators. To pursue the intriguing points raised in the letter, we performed additional analyses using the original raw data.

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Esquema

Bifactor Approaches to Psychopathology

Analytic Results

General Discussion and Future Directions

	Mr. Kim and Ms. Greene contributed equally to this research and are joint first authors.
	This study was supported, in part, by the Matt and Debra Cody Center for Autism and Developmental Disabilities. Dr. Lerner received support from NIMH grant R01MH110585 and a NARSAD Young Investigator Award (#24890) during the course of this project.
	Authorship Contribution: Hyunsik Kim and Ashley Greene performed the data analysis and interpretation under the supervision of Drs. Nicholas Eaton, Matthew Lerner, and Kenneth Gadow. Hyunsik Kim and Ashley Greene drafted the paper, and Drs. Nicholas Eaton, Matthew Lerner, and Kenneth Gadow provided critical revisions. All authors approved the final version of the paper for submission. Dr. Eaton, Ms. Greene, and Mr. Kim served as the statistical experts for this research.
	Disclosure: Dr. Gadow is a shareholder in Checkmate Plus, publisher of the Child and Adolescent Symptom Inventory – 4R. Drs. Eaton and Lerner, Mr. Kim, and Ms. Greene report no biomedical financial interests or potential conflicts of interest.
	All statements expressed in this column are those of the authors and do not reflect the opinions of the Journal of the American Academy of Child and Adolescent Psychiatry. See the Instructions for Authors for information about the preparation and submission of Letters to the Editor.