The endocannabinoid system: Novel targets for treating cancer induced bone pain - 13/11/19
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Abstract |
Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence suggested the endocannabinoid system (ECS) may play essential roles in CIBP. Here, we summarized the current understanding of the antinociceptive mechanisms of endocannabinoids in CIBP and discussed the beneficial effects of endocannabinoid for CIBP treatment. Targeting non-selective cannabinoid 1 receptors or selective cannabinoid 2 receptors, and modulation of peripheral AEA and 2-AG, as well as the inhibition the function of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have produced analgesic effects in animal models of CIBP. Management of ECS therefore appears to be a promising way for the treatment of CIBP in terms of efficacy and safety. Further clinical studies are encouraged to confirm the possible translation to humans of the very promising results already obtained in the preclinical studies.
El texto completo de este artículo está disponible en PDF.Abbreviations : 2-AG (2-arachidonoyl glycerol), ACEA, AEA, AM-1241, AM-251, AM-630, Ang II, AT1, AT2, BDNF, NR1, NR2, CaMKII, cAMP, CB, CB1R, CB2R, CBD, COX, CP-55940, CREB, Cx, Δ9-THC, DAG, DAGL, DH, DRG, ECS, ERK, ET-1, FAAH, G-CSF, GDNF, GM-CSF, GF, GPCR, GRK2, HDACs, IC, JAK, JWH-015, JNK, JZL-184, LPA, MAPK, MCP-1, MAGL, mGluR, MT-178, NGF, NAPE, NAT, NMDA, NLRP3, NR2B, PAG, PAH, PAR2, PI, PI3K, PE, PLC, PLD, PPARγ, PTHrP, PrNMI, rACC, RTKs, RVM, STAT, SR144528, WIN 55212, THC, TNF-α, TNF-β1, TRPA1, TRPV1, TrkA, URB-597, vlPAG
Keywords : Antinociception, Cancer-induced bone pain, Endocannabinoids, Endocannabinoid receptor
Esquema
Vol 120
Artículo 109504- décembre 2019 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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