Silence of FAM83H-AS1 promotes chemosensitivity of gastric cancer through Wnt/β-catenin signaling pathway - 14/03/20
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 6 |
| Iconografías | 5 |
| Vídeos | 0 |
| Otros | 0 |
Highlights |
• | LncRNA FAM83H-AS1 was high-expressed in gastric cancer. |
• | FAM83H-AS1 was related with chemotherapy insensitivity in gastric cancer. |
• | Silence of FAM83H-AS1 enhanced the CDDP and 5-FU sensitivity of SGC7901/R cells. |
• | FAM83H-AS1 promotes chemoresistance of gastric cancer through Wnt/β-catenin pathway. |
Abstract |
Gastric cancer (GC) is a malignant tumor originated from the epithelium of gastric mucosa, its incidence is second only to lung cancer in China. Chemotherapy is one of the most effective methods to treat GC, but some patients are insensitive to chemotherapeutic drugs, leading to chemotherapy failure. In this study, the expression of FAM83H-AS1 was up-regulated in GC tissues and cell lines, and was related to differentiation, invasion depth and chemotherapy insensitivity of GC patients. FAM83H-AS1 was high-expressed in chemoresistant GC tissues and cell line (SGC7901/R), and silence of FAM83H-AS1 sensitized SGC7901/R cells to cisplatin (CDDP) and 5-fluorouracil (5-FU). In addition, silence of FAM83H-AS1 could inactivate Wnt/β-catenin signaling pathway in SGC7901/R cells. The activating of Wnt/β-catenin signaling pathway reversed the promoting effect of FAM83H-AS1 silence on chemotherapy sensitivity, which meant Wnt/β-catenin signaling pathway mediated the regulation of FAM83H-AS1 on chemotherapy sensitivity in SGC7901/R cells. In conclusion, FAM83H-AS1 is related with the CDDP and 5-FU insensitivity of GC patients, silence of FAM83H-AS1 promotes chemosensitivity of GC through Wnt/β-catenin signaling pathway.
El texto completo de este artículo está disponible en PDF.Keywords : Long non-coding RNA, FAM83H-AS1, Gastric cancer, Chemosensitivity, Wnt/β-catenin signaling pathway
Esquema
Vol 125
Artículo 109961- mai 2020 Regresar al número
Artículo precedente
- Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet
- Wen Gu, Yanfang Wang, Linxi Zeng, Jincai Dong, Qian Bi, Xingxin Yang, Yanyun Che, Sen He, Jie Yu
- Data mining and systematic pharmacology to reveal the mechanisms of traditional Chinese medicine in Mycoplasma pneumoniae pneumonia treatment
- Jian hong Sun, Fei Sun, Bin Yan, Jun yi Li, De li Xin
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?